ENSG00000165304


Homo sapiens

Features
Gene ID: ENSG00000165304
  
Biological name :MELK
  
Synonyms : maternal embryonic leucine zipper kinase / MELK / Q14680
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p13.2
Gene start: 36572862
Gene end: 36677683
  
Corresponding Affymetrix probe sets: 204825_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445452
Ensembl peptide - ENSP00000443550
Ensembl peptide - ENSP00000486459
Ensembl peptide - ENSP00000487536
Ensembl peptide - ENSP00000486717
Ensembl peptide - ENSP00000486558
Ensembl peptide - ENSP00000298048
Ensembl peptide - ENSP00000437804
Ensembl peptide - ENSP00000439184
Ensembl peptide - ENSP00000439792
Ensembl peptide - ENSP00000441596
NCBI entrez gene - 9833     See in Manteia.
OMIM - 607025
RefSeq - XM_011518086
RefSeq - NM_001256691
RefSeq - NM_001256692
RefSeq - NM_001256693
RefSeq - NM_014791
RefSeq - XM_011518076
RefSeq - XM_011518077
RefSeq - XM_011518078
RefSeq - XM_011518079
RefSeq - XM_011518080
RefSeq - XM_011518081
RefSeq - XM_011518082
RefSeq - XM_011518083
RefSeq - XM_011518084
RefSeq - XM_011518085
RefSeq - NM_001256685
RefSeq - NM_001256687
RefSeq - NM_001256688
RefSeq - NM_001256689
RefSeq - NM_001256690
RefSeq Peptide - NP_001243616
RefSeq Peptide - NP_001243620
RefSeq Peptide - NP_001243621
RefSeq Peptide - NP_001243622
RefSeq Peptide - NP_055606
RefSeq Peptide - NP_001243614
RefSeq Peptide - NP_001243617
RefSeq Peptide - NP_001243618
RefSeq Peptide - NP_001243619
swissprot - A0A0D9SFL8
swissprot - A0A0D9SFF9
swissprot - A0A0D9SGI4
swissprot - Q14680
swissprot - A0A0D9SFB9
Ensembl - ENSG00000165304
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 melkENSDARG00000030759Danio rerio
 MELKENSGALG00000016438Gallus gallus
 MelkENSMUSG00000035683Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HUNK / P57058 / hormonally up-regulated Neu-associated kinaseENSG0000014214924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR034673  Maternal embryonic leucine zipper kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IDA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030097 hemopoiesis ISS
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0061351 neural precursor cell proliferation ISS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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