ENSMUSG00000054309


Mus musculus

Features
Gene ID: ENSMUSG00000054309
  
Biological name :Cpsf3
  
Synonyms : Cleavage and polyadenylation specificity factor subunit 3 / Cpsf3 / Q9QXK7
  
Possible biological names infered from orthology : cleavage and polyadenylation specific factor 3 / Q9UKF6
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.3
Gene start: 21285391
Gene end: 21315056
  
Corresponding Affymetrix probe sets: 10394892 (MoGene1.0st)   1422855_at (Mouse Genome 430 2.0 Array)   1437328_x_at (Mouse Genome 430 2.0 Array)   1437852_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068148
Ensembl peptide - ENSMUSP00000152703
Ensembl peptide - ENSMUSP00000152651
Ensembl peptide - ENSMUSP00000152601
Ensembl peptide - ENSMUSP00000152447
Ensembl peptide - ENSMUSP00000152325
Ensembl peptide - ENSMUSP00000152222
NCBI entrez gene - 54451     See in Manteia.
MGI - MGI:1859328
RefSeq - XM_017315137
RefSeq - NM_018813
RefSeq - XM_006515158
RefSeq - XM_006515159
RefSeq - XM_017315136
RefSeq Peptide - NP_061283
swissprot - A0A1Y7VNI9
swissprot - Q9QXK7
swissprot - A0A1Y7VJV9
swissprot - A0A1Y7VJU9
swissprot - A0A1Y7VJ97
swissprot - A0A1Y7VLY3
swissprot - A0A1Y7VIZ9
Ensembl - ENSMUSG00000054309
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cpsf3ENSDARG00000027649Danio rerio
 CPSF3ENSGALG00000016424Gallus gallus
 CPSF3ENSG00000119203Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ints11 / Q9CWS4 / Integrator complex subunit 11 / Q5TA45*ENSMUSG0000002903429


Protein motifs (from Interpro)
Interpro ID Name
 IPR001279  Metallo-beta-lactamase
 IPR011108  Zn-dependent metallo-hydrolase, RNA specificity domain
 IPR021718  Pre-mRNA 3"-end-processing endonuclease polyadenylation factor C-term
 IPR022712  Beta-Casp domain
 IPR036866  Ribonuclease Z/Hydroxyacylglutathione hydrolase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006398 mRNA 3"-end processing by stem-loop binding and cleavage IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IDA
 molecular_functionGO:0008409 5"-3" exonuclease activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
mRNA Splicing - Major Pathway
mRNA 3-end processing
Processing of Intronless Pre-mRNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cpetm1b(EUCOMM)Hmgu/Cpetm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cpetm1b(EUCOMM)Hmgu/Ieg

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Cpetm1b(EUCOMM)Hmgu/Cpetm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cpetm1b(EUCOMM)Hmgu/Ieg

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
Show

Allelic Composition: Cptm1b(KOMP)Wtsi/Cptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Cptm1b(KOMP)Wtsi/J

Allelic Composition: Cpsf3tm1b(EUCOMM)Wtsi/Cpsf3tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Cpsf3tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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