ENSMUSG00000054385


Mus musculus

Features
Gene ID: ENSMUSG00000054385
  
Biological name :Ceacam2
  
Synonyms : Carcinoembryonic antigen-related cell adhesion molecule 2 / Ceacam2 / Q925P2
  
Possible biological names infered from orthology : AC243967.1 / carcinoembryonic antigen related cell adhesion molecule 1 / carcinoembryonic antigen related cell adhesion molecule 3 / carcinoembryonic antigen related cell adhesion molecule 5 / carcinoembryonic antigen related cell adhesion molecule 6 / carcinoembryonic antigen related cell adhesion molecule 7 / carcinoembryonic antigen related cell adhesion molecule 8 / CEACAM1 / CEACAM3 / CEACAM5 / CEACAM6 / CEACAM7 / CEACAM8 / P06731 / P11464 / P11465 / P13688 / P31997 / P40198 / P40199 / pregnancy specific beta-1-glycoprotein 1 / pregnancy specific beta-1-glycoprotein 11 / pregnancy specific beta-1-glycoprotein 2 / pregnancy specific beta-1-glycoprotein 3 / pregnancy specific beta-1-glycoprotein 4 / pregnancy specific beta-1-glycoprotein 5 / pregnancy specific beta-1-glycoprotein 6 / pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene) / pregnancy specific beta-1-glycoprotein 8 / pregnancy specific beta-1-glycoprotein 9 / PSG1 / PSG11 / PSG2 / PSG3 / PSG4 / PSG5 / PSG6 / PSG7 / PSG8 / PSG9 / Q00887 / Q00888 / Q00889 / Q14002 / Q15238 / Q16557 / Q9UQ72 / Q9UQ74
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 25516042
Gene end: 25539857
  
Corresponding Affymetrix probe sets: 10561055 (MoGene1.0st)   1421603_a_at (Mouse Genome 430 2.0 Array)   1422123_s_at (Mouse Genome 430 2.0 Array)   1425538_x_at (Mouse Genome 430 2.0 Array)   1425675_s_at (Mouse Genome 430 2.0 Array)   1427630_x_at (Mouse Genome 430 2.0 Array)   1460681_at (Mouse Genome 430 2.0 Array)   1460682_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048118
Ensembl peptide - ENSMUSP00000064255
Ensembl peptide - ENSMUSP00000068540
NCBI entrez gene - 26367     See in Manteia.
MGI - MGI:1347246
RefSeq - NM_001113369
RefSeq - NM_001113368
RefSeq - NM_007543
RefSeq Peptide - NP_001106839
RefSeq Peptide - NP_001106840
RefSeq Peptide - NP_031569
swissprot - Q925P2
Ensembl - ENSMUSG00000054385
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-250k15.9ENSDARG00000095134Danio rerio
 AC243967.1ENSG00000267881Homo sapiens
 P06731ENSG00000105388Homo sapiens
 P13688ENSG00000079385Homo sapiens
 P31997ENSG00000124469Homo sapiens
 P40198ENSG00000170956Homo sapiens
 P40199ENSG00000086548Homo sapiens
 PSG1ENSG00000231924Homo sapiens
 PSG11ENSG00000243130Homo sapiens
 PSG2ENSG00000242221Homo sapiens
 PSG3ENSG00000221826Homo sapiens
 PSG4ENSG00000243137Homo sapiens
 PSG5ENSG00000204941Homo sapiens
 PSG6ENSG00000170848Homo sapiens
 PSG7ENSG00000221878Homo sapiens
 PSG8ENSG00000124467Homo sapiens
 PSG9ENSG00000183668Homo sapiens
 Q14002ENSG00000007306Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P31809 / Ceacam1 / Carcinoembryonic antigen-related cell adhesion molecule 1 / PSG3* / PSG4* / PSG5* / PSG1* / PSG6* / PSG7* / PSG8* / PSG9* / PSG2* / PSG11* / Q9UQ74* / P11464* / P11465* ...ENSMUSG0000007427282
Ceacam3 / carcinoembryonic antigen-related cell adhesion molecule 3 / PSG3* / PSG4* / PSG5* / PSG6* / PSG7* / PSG8* / PSG9* / PSG2* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* ...ENSMUSG0000005322826
Q9D2Z1 / Ceacam20 / Carcinoembryonic antigen-related cell adhesion molecule 20 ENSMUSG0000007077725
Psg21 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000007079623
Psg22 / Q810J1 / Pregnancy-specific glycoprotein 22 / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG9* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31...ENSMUSG0000004490323
Psg26 / pregnancy-specific glycoprotein 26 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000007079923
Psg19 / pregnancy specific glycoprotein 19 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG8* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000000454223
Psg18 / pregnancy specific glycoprotein 18 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG8* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000000350523
E9QA28 / Ceacam16 / Carcinoembryonic antigen-related cell adhesion molecule 16 / Q2WEN9*ENSMUSG0000001468623
Psg17 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000000454023
Psg20 / pregnancy-specific glycoprotein 20 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P4...ENSMUSG0000006330522
Psg23 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000007435922
Psg25 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000007079822
Psg28 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000003037322
Psg27 / pregnancy-specific glycoprotein 27 / PSG9* / PSG6* / PSG5* / PSG4* / PSG3* / PSG8* / PSG2* / PSG7* / PSG1* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40...ENSMUSG0000007079722
Q3UKK2 / Ceacam5 / Carcinoembryonic antigen-related cell adhesion molecule 5 / PSG7* / PSG6* / PSG5* / PSG1* / PSG4* / PSG3* / PSG2* / PSG9* / PSG8* / PSG11* / Q9UQ74* / P06731* / P11464* ...ENSMUSG0000000878922
Ceacam10 / PSG2* / PSG3* / PSG4* / PSG5* / PSG6* / PSG7* / PSG8* / PSG9* / PSG1* / PSG11* / Q9UQ74* / Q00887* / Q00889* / Q14002* / Q15238* / Q16557* / Q9UQ72* / P06731* / P11464* / P11465*...ENSMUSG0000005416920
Psg29 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000002315920
Q9D871 / Ceacam18 / Carcinoembryonic antigen-related cell adhesion molecule 18 / A8MTB9*ENSMUSG0000003047219
Psg16 / PSG8* / PSG7* / PSG6* / PSG5* / PSG4* / PSG3* / PSG2* / PSG1* / PSG9* / PSG11* / Q9UQ74* / P06731* / P11464* / P11465* / P13688* / P31997* / P40198* / P40199* / Q00887* / Q00888* / ...ENSMUSG0000006676019


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016032 viral process IEA
 biological_processGO:0070348 negative regulation of brown fat cell proliferation IMP
 biological_processGO:2000252 negative regulation of feeding behavior IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0042101 T cell receptor complex ISO
 molecular_functionGO:0003779 actin binding ISO
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0019903 protein phosphatase binding ISO
 molecular_functionGO:0031005 filamin binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:1990782 protein tyrosine kinase binding ISO


Pathways (from Reactome)
Pathway description
Fibronectin matrix formation
Post-translational modification: synthesis of GPI-anchored proteins
Cell surface interactions at the vascular wall
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009286 increased abdominal fat pad weight "greater than average weight of the encapsulated adipose tissue in the abdomen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0014172 decreased fatty acid oxidation 
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0030022 decreased muscle cell glucose uptake "reduced ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Ryr1tm1.1Inp/Ryr1tm1.1Inp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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