ENSG00000079385


Homo sapiens

Features
Gene ID: ENSG00000079385
  
Biological name :CEACAM1
  
Synonyms : carcinoembryonic antigen related cell adhesion molecule 1 / CEACAM1 / P13688
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.2
Gene start: 42507304
Gene end: 42561234
  
Corresponding Affymetrix probe sets: 206576_s_at (Human Genome U133 Plus 2.0 Array)   209498_at (Human Genome U133 Plus 2.0 Array)   210610_at (Human Genome U133 Plus 2.0 Array)   211883_x_at (Human Genome U133 Plus 2.0 Array)   211889_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472633
Ensembl peptide - ENSP00000471566
Ensembl peptide - ENSP00000471918
Ensembl peptide - ENSP00000161559
Ensembl peptide - ENSP00000244291
Ensembl peptide - ENSP00000351165
Ensembl peptide - ENSP00000384083
Ensembl peptide - ENSP00000384709
NCBI entrez gene - 634     See in Manteia.
OMIM - 109770
RefSeq - XM_011527206
RefSeq - NM_001024912
RefSeq - NM_001184813
RefSeq - NM_001184815
RefSeq - NM_001184816
RefSeq - NM_001205344
RefSeq - NM_001712
RefSeq Peptide - NP_001192273
RefSeq Peptide - NP_001703
RefSeq Peptide - NP_001171742
RefSeq Peptide - NP_001020083
RefSeq Peptide - NP_001171744
RefSeq Peptide - NP_001171745
swissprot - P13688
swissprot - M0R2K4
swissprot - M0R109
Ensembl - ENSG00000079385
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-250k15.9ENSDARG00000095134Danio rerio
 Ceacam10ENSMUSG00000054169Mus musculus
 Ceacam11ENSMUSG00000030368Mus musculus
 Ceacam12ENSMUSG00000030366Mus musculus
 Ceacam13ENSMUSG00000057195Mus musculus
 Ceacam14ENSMUSG00000023185Mus musculus
 Ceacam3ENSMUSG00000053228Mus musculus
 P31809ENSMUSG00000074272Mus musculus
 Psg16ENSMUSG00000066760Mus musculus
 Psg17ENSMUSG00000004540Mus musculus
 Psg18ENSMUSG00000003505Mus musculus
 Psg19ENSMUSG00000004542Mus musculus
 Psg20ENSMUSG00000063305Mus musculus
 Psg21ENSMUSG00000070796Mus musculus
 Psg22ENSMUSG00000044903Mus musculus
 Psg23ENSMUSG00000074359Mus musculus
 Psg25ENSMUSG00000070798Mus musculus
 Psg26ENSMUSG00000070799Mus musculus
 Psg27ENSMUSG00000070797Mus musculus
 Psg28ENSMUSG00000030373Mus musculus
 Psg29ENSMUSG00000023159Mus musculus
 Q3UKK2ENSMUSG00000008789Mus musculus
 Q925P2ENSMUSG00000054385Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P06731 / CEACAM5 / carcinoembryonic antigen related cell adhesion molecule 5ENSG0000010538862
P40199 / CEACAM6 / carcinoembryonic antigen related cell adhesion molecule 6ENSG0000008654854
P31997 / CEACAM8 / carcinoembryonic antigen related cell adhesion molecule 8ENSG0000012446950
PSG8 / Q9UQ74 / pregnancy specific beta-1-glycoprotein 8ENSG0000012446738
PSG9 / Q00887 / pregnancy specific beta-1-glycoprotein 9ENSG0000018366837
PSG6 / Q00889 / pregnancy specific beta-1-glycoprotein 6ENSG0000017084837
PSG1 / P11464 / pregnancy specific beta-1-glycoprotein 1ENSG0000023192437
PSG4 / Q00888 / pregnancy specific beta-1-glycoprotein 4ENSG0000024313736
PSG3 / Q16557 / pregnancy specific beta-1-glycoprotein 3ENSG0000022182636
PSG11 / Q9UQ72 / pregnancy specific beta-1-glycoprotein 11ENSG0000024313036
PSG2 / P11465 / pregnancy specific beta-1-glycoprotein 2ENSG0000024222136
Q14002 / CEACAM7 / carcinoembryonic antigen related cell adhesion molecule 7ENSG0000000730633
P40198 / CEACAM3 / carcinoembryonic antigen related cell adhesion molecule 3ENSG0000017095630
CEACAM20 / carcinoembryonic antigen related cell adhesion molecule 20ENSG0000027377727
Q3KPI0 / CEACAM21 / carcinoembryonic antigen related cell adhesion molecule 21ENSG0000000712927
AC243967.1ENSG0000026788125
PSG5 / Q15238 / pregnancy specific beta-1-glycoprotein 5ENSG0000020494125
PSG7 / pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)ENSG0000022187823
Q2WEN9 / CEACAM16 / carcinoembryonic antigen related cell adhesion molecule 16ENSG0000021389223
O75871 / CEACAM4 / carcinoembryonic antigen related cell adhesion molecule 4ENSG0000010535221


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis NAS
 biological_processGO:0001558 regulation of cell growth ISS
 biological_processGO:0001568 blood vessel development ISS
 biological_processGO:0001915 negative regulation of T cell mediated cytotoxicity IDA
 biological_processGO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
 biological_processGO:0006469 negative regulation of protein kinase activity ISS
 biological_processGO:0007155 cell adhesion ISS
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules NAS
 biological_processGO:0007229 integrin-mediated signaling pathway NAS
 biological_processGO:0010594 regulation of endothelial cell migration ISS
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0015721 bile acid and bile salt transport ISS
 biological_processGO:0016477 cell migration NAS
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0030853 negative regulation of granulocyte differentiation ISS
 biological_processGO:0032692 negative regulation of interleukin-1 production ISS
 biological_processGO:0032869 cellular response to insulin stimulus ISS
 biological_processGO:0035726 common myeloid progenitor cell proliferation ISS
 biological_processGO:0038016 insulin receptor internalization ISS
 biological_processGO:0038158 granulocyte colony-stimulating factor signaling pathway ISS
 biological_processGO:0042058 regulation of epidermal growth factor receptor signaling pathway ISS
 biological_processGO:0043116 negative regulation of vascular permeability ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043318 negative regulation of cytotoxic T cell degranulation IDA
 biological_processGO:0044319 wound healing, spreading of cells IDA
 biological_processGO:0045601 regulation of endothelial cell differentiation ISS
 biological_processGO:0045717 negative regulation of fatty acid biosynthetic process ISS
 biological_processGO:0050860 negative regulation of T cell receptor signaling pathway IDA
 biological_processGO:0050900 leukocyte migration TAS
 biological_processGO:0051055 negative regulation of lipid biosynthetic process ISS
 biological_processGO:0060312 regulation of blood vessel remodeling ISS
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0090331 negative regulation of platelet aggregation ISS
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules ISS
 biological_processGO:1901143 insulin catabolic process ISS
 biological_processGO:1903385 regulation of homophilic cell adhesion ISS
 biological_processGO:1903670 regulation of sprouting angiogenesis ISS
 biological_processGO:2000346 negative regulation of hepatocyte proliferation ISS
 biological_processGO:2001214 positive regulation of vasculogenesis ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005912 adherens junction ISS
 cellular_componentGO:0009925 basal plasma membrane ISS
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0016328 lateral plasma membrane ISS
 cellular_componentGO:0030054 cell junction ISS
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0042101 T cell receptor complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070821 tertiary granule membrane TAS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0003779 actin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISS
 molecular_functionGO:0015125 bile acid transmembrane transporter activity ISS
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0031005 filamin binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046983 protein dimerization activity ISS
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000079385 P13688 / CEACAM1 / carcinoembryonic antigen related cell adhesion molecule 1  / complex / reaction
 ENSG00000086548 P40199 / CEACAM6 / carcinoembryonic antigen related cell adhesion molecule 6  / complex / reaction
 ENSG00000124469 P31997 / CEACAM8 / carcinoembryonic antigen related cell adhesion molecule 8  / reaction / complex






 

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