Manteia - Molecule gene

ENSMUSG00000054612

Mus musculus

Features

Gene ID:	ENSMUSG00000054612

Biological name :	Mgmt

Synonyms :	Methylated-DNA--protein-cysteine methyltransferase / Mgmt / P26187

Possible biological names infered from orthology :	O-6-methylguanine-DNA methyltransferase / P16455

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	F3
Gene start:	136894614
Gene end:	137130266

Corresponding Affymetrix probe sets:	10558441 (MoGene1.0st) 1421309_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000080224 NCBI entrez gene - 17314 See in Manteia. MGI - MGI:96977 RefSeq - XM_006507410 RefSeq - NM_008598 RefSeq - XM_006507406 RefSeq - XM_006507409 RefSeq - XM_006507405 RefSeq Peptide - NP_032624 swissprot - P26187 Ensembl - ENSMUSG00000054612

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mgmt	ENSDARG00000043275	Danio rerio
MGMT	ENSGALG00000042949	Gallus gallus
MGMT	ENSG00000170430	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001497	Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
IPR008332	Methylguanine DNA methyltransferase, ribonuclease-like domain
IPR014048	Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
IPR036217	Methylated DNA-protein cysteine methyltransferase, DNA binding domain
IPR036388	Winged helix-like DNA-binding domain superfamily
IPR036631	Methylated DNA-protein cysteine methyltransferase domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006281	DNA repair	IMP
biological_process	GO:0006307	DNA dealkylation involved in DNA repair	IEA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IMP
biological_process	GO:0009636	response to toxic substance	IEA
biological_process	GO:0014070	response to organic cyclic compound	IEA
biological_process	GO:0032259	methylation	IEA
biological_process	GO:0034599	cellular response to oxidative stress	IEA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0043066	negative regulation of apoptotic process	IEA
biological_process	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP
biological_process	GO:0045471	response to ethanol	IEA
biological_process	GO:0045739	positive regulation of DNA repair	IEA
biological_process	GO:0051593	response to folic acid	IEA
biological_process	GO:0060548	negative regulation of cell death	IEA
biological_process	GO:0060644	mammary gland epithelial cell differentiation	IEA
biological_process	GO:0071407	cellular response to organic cyclic compound	IEA
biological_process	GO:0071479	cellular response to ionizing radiation	IEA
biological_process	GO:2000781	positive regulation of double-strand break repair	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	IEA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003824	catalytic activity	IEA
molecular_function	GO:0003908	methylated-DNA-[protein]-cysteine S-methyltransferase activity	IEA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0008168	methyltransferase activity	IDA
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002024	T cell derived lymphoma	"group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Mlh1^tm1Mse/Mlh1^tm1Mse Genetic Background: involves: 129S/SvEv Allelic Composition: Mgmt^tm1Mse/Mgmt^tm1Mse,Mlh1^tm1Mse/Mlh1^tm1Mse Genetic Background: involves: 129S/SvEv
MP:0002048	lung adenoma	"benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]	Show Allelic Composition: Mlh1^tm1Mse/Mlh1^tm1Mse Genetic Background: involves: 129S/SvEv
MP:0005165	increased susceptibility to injury	"greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex},Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex},Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mlh1^tm1Mse/Mlh1^tm1Mse Genetic Background: involves: 129S/SvEv
MP:0009172	small pancreatic islets	"decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]	Show Allelic Composition: Mdm4^{Gt(VICTR20)7Lex}/Mdm4^{Gt(VICTR20)7Lex},Trp53^tm1Tyj/Trp53⁺ Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Mlh1^tm1Mse/Mlh1^tm1Mse Genetic Background: involves: 129S/SvEv

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr