ENSG00000170430


Homo sapiens

Features
Gene ID: ENSG00000170430
  
Biological name :MGMT
  
Synonyms : MGMT / O-6-methylguanine-DNA methyltransferase / P16455
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q26.3
Gene start: 129467184
Gene end: 129768007
  
Corresponding Affymetrix probe sets: 204880_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302111
NCBI entrez gene - 4255     See in Manteia.
OMIM - 156569
RefSeq - XM_005252682
RefSeq - NM_002412
RefSeq Peptide - NP_002403
swissprot - P16455
swissprot - B4DEE8
Ensembl - ENSG00000170430
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mgmtENSDARG00000043275Danio rerio
 MGMTENSGALG00000042949Gallus gallus
 MgmtENSMUSG00000054612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001497  Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
 IPR008332  Methylguanine DNA methyltransferase, ribonuclease-like domain
 IPR014048  Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
 IPR036217  Methylated DNA-protein cysteine methyltransferase, DNA binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036631  Methylated DNA-protein cysteine methyltransferase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006266 DNA ligation TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006306 DNA methylation IEA
 biological_processGO:0006307 DNA dealkylation involved in DNA repair TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 biological_processGO:2000781 positive regulation of double-strand break repair IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0016020 membrane HDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008168 methyltransferase activity TAS
 molecular_functionGO:0009008 DNA-methyltransferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
MGMT-mediated DNA damage reversal


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000488 Retinopathy 
Show

 HP:0000958 Dry skin 
Show

 HP:0001480 Freckling 
Show

 HP:0001595 Hair abnormality 
Show

 HP:0002071 Extrapyramidal signs 
Show

 HP:0002861 Malignant melanoma "A malignant skin tumor of originating from melanocytes, pigment cells normally present in the epidermis and sometimes in the dermis." [HPO:curators]
Show

 HP:0002894 Pancreatic cancer 
Show

 HP:0003764 Abnormal or excess nevi 
Show

 HP:0006753 Increased gastric cancer 
Show

 HP:0100013 Neoplasia of the breast 
Show

 HP:0100763 Abnormality of the lymphatic system 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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