ENSMUSG00000056749


Mus musculus

Features
Gene ID: ENSMUSG00000056749
  
Biological name :Nfil3
  
Synonyms : Nfil3 / Nuclear factor interleukin-3-regulated protein / O08750
  
Possible biological names infered from orthology : nuclear factor, interleukin 3 regulated / Q16649
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 52967209
Gene end: 52981073
  
Corresponding Affymetrix probe sets: 10409278 (MoGene1.0st)   1418932_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065363
NCBI entrez gene - 18030     See in Manteia.
MGI - MGI:109495
RefSeq - XM_017315418
RefSeq - NM_017373
RefSeq - XM_006516877
RefSeq - XM_011244379
RefSeq Peptide - NP_059069
swissprot - O08750
Ensembl - ENSMUSG00000056749
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfil3ENSDARG00000042977Danio rerio
 NFIL3ENSGALG00000015209Gallus gallus
 NFIL3ENSG00000165030Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR010533  Vertebrate interleukin-3 regulated transcription factor
 IPR016743  Nuclear factor interleukin-3-regulated protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007623 circadian rhythm IBA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0002439 abnormal plasma cell morphology/development "anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm12(Ple177-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+,Tg(LHX3-cre)#Sjr/0
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C3H * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm12(Ple177-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

Allelic Composition: Nfil3tm1Look/Nfil3tm1Look
Genetic Background: B6.129X1-Nfil3tm1Look

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ncoa3tm1b(EUCOMM)Wtsi/Ncoa3+
Genetic Background: C57BL/6N-Ncoa3tm1b(EUCOMM)Wtsi/H

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

Allelic Composition: Nfil3tm1.1Brad/Nfil3+
Genetic Background: B6.Cg-Nfil3tm1.1Brad

Allelic Composition: Nfil3tm1Look/Nfil3tm1Look
Genetic Background: B6.129X1-Nfil3tm1Look

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

Allelic Composition: Nfil3tm1Look/Nfil3tm1Look
Genetic Background: B6.129X1-Nfil3tm1Look

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm12(Ple177-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Dicer1tm1Bdh/Dicer1tm1Bdh
Genetic Background: involves: 129

Allelic Composition: Nfil3tm1Look/Nfil3tm1Look
Genetic Background: B6.129X1-Nfil3tm1Look

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Il10tm1Keny/Il10+,Nfil3tm1.1Kubo/Nfil3tm1.1Kubo
Genetic Background: involves: 129 * C57BL/6

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Look/Nfil3tm1Look
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Hprttm12(Ple177-EGFP/cre)Ems/Y
Genetic Background: B6.129P2(129S4)-Hprttm12(Ple177-EGFP/cre)Ems

 MP:0008712 decreased interleukin-9 secretion "reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells" [MESH:D12.644.276.374.465.509]
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Allelic Composition: Amhr2tm3(cre)Bhr/Amhr2+,Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0010219 increased T-helper 17 cell number "increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0011078 increased macrophage cytokine production "greater production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: B6.129S6-Nfil3tm1Pbro

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Nfil3tm1Pbro/Nfil3tm1Pbro
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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