ENSMUSG00000057110


Mus musculus

Features
Gene ID: ENSMUSG00000057110
  
Biological name :Cntrl
  
Synonyms : A2AL36 / Centriolin / Cntrl
  
Possible biological names infered from orthology : Q7Z7A1
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 35109492
Gene end: 35178822
  
Corresponding Affymetrix probe sets: 10471608 (MoGene1.0st)   1421004_at (Mouse Genome 430 2.0 Array)   1421005_at (Mouse Genome 430 2.0 Array)   1435779_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108657
Ensembl peptide - ENSMUSP00000143914
Ensembl peptide - ENSMUSP00000143087
Ensembl peptide - ENSMUSP00000142683
Ensembl peptide - ENSMUSP00000119760
Ensembl peptide - ENSMUSP00000118731
Ensembl peptide - ENSMUSP00000108660
Ensembl peptide - ENSMUSP00000028235
Ensembl peptide - ENSMUSP00000028237
Ensembl peptide - ENSMUSP00000108655
Ensembl peptide - ENSMUSP00000108656
NCBI entrez gene - 26920     See in Manteia.
MGI - MGI:1889576
RefSeq - XM_006498068
RefSeq - XM_006498075
RefSeq - XM_006498074
RefSeq - XM_006498073
RefSeq - XM_006498072
RefSeq - XM_006498071
RefSeq - NM_001290635
RefSeq - NM_012018
RefSeq - XM_006498069
RefSeq - XM_006498076
RefSeq Peptide - NP_036148
RefSeq Peptide - NP_001277564
swissprot - R4GML4
swissprot - R4GML3
swissprot - E9Q9E7
swissprot - F6QP53
swissprot - A0A0G2JE96
swissprot - A0A0G2JFA2
swissprot - A0A0J9YTY9
swissprot - A2AL36
swissprot - A2AS42
Ensembl - ENSMUSG00000057110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cntrlENSDARG00000088492Danio rerio
 CNTRLENSGALG00000001513Gallus gallus
 CNTRLENSG00000119397Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lrrcc1 / leucine rich repeat and coiled-coil centrosomal protein 1 / Q9C099*ENSMUSG000000275508


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR028640  Centriolin
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060976 coronary vasculature development IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0090543 Flemming body IEA
 cellular_componentGO:0097431 mitotic spindle pole IDA
 cellular_componentGO:0120103 centriolar subdistal appendage ISO
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000536 hydroureter "distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004860 dilated kidney collecting duct "stretched or widened aperture of the luminal space of the collecting ducts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006124 tricuspid valve stenosis "abnormal narrowing of the tricuspid valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010422 heart right ventricle hypoplasia "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010457 pulmonary artery stenosis "constriction or narrowing of the pulmonary artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax7tm1.1(rtTA)Sjl/Pax7tm1.1(rtTA)Sjl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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