ENSMUSG00000057337


Mus musculus

Features
Gene ID: ENSMUSG00000057337
  
Biological name :Chst3
  
Synonyms : Carbohydrate sulfotransferase 3 / Chst3 / O88199
  
Possible biological names infered from orthology : Q7LGC8
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 60181532
Gene end: 60219260
  
Corresponding Affymetrix probe sets: 10369301 (MoGene1.0st)   1460322_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065010
Ensembl peptide - ENSMUSP00000126281
Ensembl peptide - ENSMUSP00000131532
NCBI entrez gene - 53374     See in Manteia.
MGI - MGI:1858224
RefSeq - XM_017314030
RefSeq - NM_016803
RefSeq - XM_011243510
RefSeq - XM_011243512
RefSeq - XM_011243513
RefSeq Peptide - NP_058083
swissprot - O88199
swissprot - G5E8X5
Ensembl - ENSMUSG00000057337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chst3aENSDARG00000061070Danio rerio
 chst3bENSDARG00000116042Danio rerio
 CHST3ENSGALG00000024056Gallus gallus
 CHST3ENSG00000122863Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chst1 / Q9EQC0 / Carbohydrate sulfotransferase 1 / O43916*ENSMUSG0000002722136
Chst5 / Q9QUP4 / Carbohydrate sulfotransferase 5 / CHST6* / Q9GZS9* / Q9GZX3* / carbohydrate sulfotransferase 6*ENSMUSG0000003195226
Chst4 / carbohydrate sulfotransferase 4 / Q8NCG5*ENSMUSG0000003593024
Chst7 / Q9EP78 / Carbohydrate sulfotransferase 7 / Q9NS84*ENSMUSG0000003734723
Chst2 / Q80WV3 / Carbohydrate sulfotransferase 2 / Q9Y4C5*ENSMUSG0000003335023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000863  Sulfotransferase domain
 IPR016469  Carbohydrate sulfotransferase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006790 sulfur compound metabolic process IEA
 biological_processGO:0030206 chondroitin sulfate biosynthetic process IEA
 biological_processGO:0043029 T cell homeostasis IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IBA
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0008459 chondroitin 6-sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0050698 proteoglycan sulfotransferase activity IMP


Pathways (from Reactome)
Pathway description
Chondroitin sulfate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003863 decreased aggression towards mice "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: a/a,Tyrc-i/Tyrc-i
Genetic Background: involves: STOCK Tyrc-r

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4tm2.1Cxd,Tg(Pou5f1-cre/ERT2)#Ysa/0
Genetic Background: involves: 129S6/SvEvTac

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacng4tm1Dgen/Cacng4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Chst3tm1Tmu/Chst3tm1Tmu
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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