ENSMUSG00000058239


Mus musculus

Features
Gene ID: ENSMUSG00000058239
  
Biological name :Usf2
  
Synonyms : Q64705 / upstream transcription factor 2 / Usf2
  
Possible biological names infered from orthology : Q15853 / upstream transcription factor 2, c-fos interacting
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 30945248
Gene end: 30956803
  
Corresponding Affymetrix probe sets: 10562172 (MoGene1.0st)   1418241_at (Mouse Genome 430 2.0 Array)   1460228_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132256
Ensembl peptide - ENSMUSP00000132232
Ensembl peptide - ENSMUSP00000132833
Ensembl peptide - ENSMUSP00000125520
Ensembl peptide - ENSMUSP00000127908
Ensembl peptide - ENSMUSP00000130298
Ensembl peptide - ENSMUSP00000132021
NCBI entrez gene - 22282     See in Manteia.
MGI - MGI:99961
RefSeq - XM_006539735
RefSeq - NM_011680
RefSeq - XM_006539733
RefSeq - XM_006539734
RefSeq Peptide - NP_035810
swissprot - E9PXC2
swissprot - E9PZY3
swissprot - F6PWU6
swissprot - F6WLF9
swissprot - F8WI12
swissprot - Q64705
Ensembl - ENSMUSG00000058239
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usf2ENSDARG00000020228Danio rerio
 USF2ENSG00000105698Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usf1 / Q61069 / upstream transcription factor 1 / P22415*ENSMUSG0000002664142


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose ISO
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II ISO
 biological_processGO:0007595 lactation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0055088 lipid homeostasis IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043425 bHLH transcription factor binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0008237 abnormal ventral coat pigmentation "irregular or unusual pigmentation of ventrum hair in relation to control animals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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