ENSMUSG00000026641


Mus musculus

Features
Gene ID: ENSMUSG00000026641
  
Biological name :Usf1
  
Synonyms : Q61069 / upstream transcription factor 1 / Usf1
  
Possible biological names infered from orthology : P22415
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H3
Gene start: 171411313
Gene end: 171419142
  
Corresponding Affymetrix probe sets: 10351616 (MoGene1.0st)   1426164_a_at (Mouse Genome 430 2.0 Array)   1448805_at (Mouse Genome 430 2.0 Array)   1459758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001284
Ensembl peptide - ENSMUSP00000125363
Ensembl peptide - ENSMUSP00000125729
Ensembl peptide - ENSMUSP00000128913
Ensembl peptide - ENSMUSP00000124000
NCBI entrez gene - 22278     See in Manteia.
MGI - MGI:99542
RefSeq - NM_001305676
RefSeq - NM_001305677
RefSeq - NM_001305678
RefSeq - NM_009480
RefSeq Peptide - NP_033506
RefSeq Peptide - NP_001292605
RefSeq Peptide - NP_001292606
RefSeq Peptide - NP_001292607
swissprot - E9Q722
swissprot - E0CYP7
swissprot - Q3UQH7
swissprot - Q61069
swissprot - F8WGH6
Ensembl - ENSMUSG00000026641
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usf1ENSDARG00000041689Danio rerio
 usf1lENSDARG00000014463Danio rerio
 USF1ENSG00000158773Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Usf2 / Q64705 / upstream transcription factor 2 / Q15853* / upstream transcription factor 2, c-fos interacting*ENSMUSG0000005823946


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose ISO
 biological_processGO:0001666 response to hypoxia ISO
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II ISO
 biological_processGO:0009411 response to UV IMP
 biological_processGO:0019086 late viral transcription ISO
 biological_processGO:0032869 cellular response to insulin stimulus ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0055088 lipid homeostasis IMP
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex ISO
 cellular_componentGO:0016589 NURF complex ISO
 cellular_componentGO:0048188 Set1C/COMPASS complex ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0042826 histone deacetylase binding ISO
 molecular_functionGO:0043425 bHLH transcription factor binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001446 whisker trimming "biting of the whiskers or facial hair by cagemates" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Usf1tm1Svl/Usf1+,Usf2tm1Svl/Usf2+
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

 MP:0002808 barbering "the biting and ingesting of hair (self, mate, pups); recognized as patches of unevenly chopped hair; seldom is the underlying skin inflamed" [What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009358 environmentally induced seizures "relatively mild but sudden stimulation due to changes in ambient habitat including lighting, sounds, touching, and/ or moving cage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Amhtm1Bhr/Amhtm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Usf1tm1Msw/Usf1+,Usf2tm1Msw/Usf2tm1Msw
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rad52tm1Aps/Rad52tm1Aps,Rad54ltm1Jhjh/Rad54ltm1Jhjh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020467 abnormal circadian behavior "any anomaly in the specific behavior of an organism that recurs with a regularity of approximately 24 hours" [GO:0048512]
Show

Allelic Composition: Slc45a2uw-8Btlr/Slc45a2uw-8Btlr
Genetic Background: C57BL/6J-Slc45a2uw-8Btlr

Allelic Composition: Usf1Gt(W233A07)Wrst/Usf1Gt(W233A07)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0020468 abnormal circadian behavior period "any change in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Clockm1Jt/Clock+,Per2tm1Jt/Per2+,Usf1soc/?
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6J

 MP:0020469 prolonged circadian behavior period "increase in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Usf1Gt(W233A07)Wrst/Usf1Gt(W233A07)Wrst
Genetic Background: involves: 129S2/SvPas * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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