ENSMUSG00000058740


Mus musculus

Features
Gene ID: ENSMUSG00000058740
  
Biological name :Kcnt1
  
Synonyms : Kcnt1 / Potassium channel subfamily T member 1 / Q6ZPR4
  
Possible biological names infered from orthology : potassium sodium-activated channel subfamily T member 1 / Q5JUK3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 25863734
Gene end: 25918273
  
Corresponding Affymetrix probe sets: 10470214 (MoGene1.0st)   1439486_at (Mouse Genome 430 2.0 Array)   1441511_at (Mouse Genome 430 2.0 Array)   1458428_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109809
Ensembl peptide - ENSMUSP00000039058
Ensembl peptide - ENSMUSP00000109813
Ensembl peptide - ENSMUSP00000143482
Ensembl peptide - ENSMUSP00000143472
Ensembl peptide - ENSMUSP00000143106
Ensembl peptide - ENSMUSP00000142870
Ensembl peptide - ENSMUSP00000142532
Ensembl peptide - ENSMUSP00000132212
NCBI entrez gene - 227632     See in Manteia.
MGI - MGI:1924627
RefSeq - XM_017317207
RefSeq - XM_006497892
RefSeq - XM_006497893
RefSeq - XM_006497894
RefSeq - XM_006497895
RefSeq - XM_006497896
RefSeq - XM_017317195
RefSeq - XM_017317196
RefSeq - XM_017317197
RefSeq - XM_017317198
RefSeq - XM_017317199
RefSeq - XM_017317204
RefSeq - XM_017317206
RefSeq - NM_001145403
RefSeq - NM_001302351
RefSeq - NM_175462
RefSeq - XM_006497877
RefSeq - XM_006497878
RefSeq - XM_006497879
RefSeq - XM_006497880
RefSeq - XM_006497881
RefSeq - XM_006497882
RefSeq - XM_006497883
RefSeq - XM_006497884
RefSeq - XM_006497886
RefSeq - XM_006497889
RefSeq - XM_006497891
RefSeq Peptide - NP_780671
RefSeq Peptide - NP_001138875
RefSeq Peptide - NP_001289280
swissprot - A2AHB7
swissprot - A0A0G2JG99
swissprot - A0A0G2JG91
swissprot - C0KTP6
swissprot - Q6ZPR4
swissprot - A0A0G2JDW4
swissprot - A0A0G2JER3
swissprot - A2AHB9
swissprot - A2AHB8
Ensembl - ENSMUSG00000058740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KCNT1ENSG00000107147Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnt2 / potassium sodium-activated channel subfamily T member 2 / Q6UVM3*ENSMUSG0000005272670
Kcnma1 / potassium large conductance calcium-activated channel, subfamily M, alpha member 1 / Q12791* / potassium calcium-activated channel subfamily M alpha 1*ENSMUSG0000006314218
Kcnu1 / A8MYU2* / potassium calcium-activated channel subfamily U member 1*ENSMUSG0000003157616


Protein motifs (from Interpro)
Interpro ID Name
 IPR003929  Potassium channel, BK, alpha subunit
 IPR013099  Potassium channel domain
 IPR036721  Regulator of K+ conductance, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0015269 calcium-activated potassium channel activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wdr13tm1Kuma/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi,Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi,Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Kcnt1tm1.1Acsc/Kcnt1tm1.1Acsc,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: BALB/cJ * C57BL/6 * C57BL/6N * DBA/2

 MP:0003488 decreased channel response intensity 
Show

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcnt1tm1.2Clin/Kcnt1+
Genetic Background: B6.Cg-Kcnt1tm1.2Clin

 MP:0008532 decreased chemical nociceptive threshold "a lower than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

 MP:0010055 abnormal sensory neuron physiology "any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi,Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0010072 increased pruritus "abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sod2tm1Shs/Sod2tm1Shs,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1+
Genetic Background: B6.Cg-Kcnt1tm1.2Clin

Allelic Composition: Kcnt1tm1.2Clin/Kcnt1tm1.2Clin,Kcnt2tm1.2Clin/Kcnt2tm1.2Clin
Genetic Background: B6.Cg-Kcnt2tm1.2Clin Kcnt1tm1.2Clin

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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