ENSMUSG00000058886


Mus musculus

Features
Gene ID: ENSMUSG00000058886
  
Biological name :Deaf1
  
Synonyms : Deaf1 / Deformed epidermal autoregulatory factor 1 homolog / Q9Z1T5
  
Possible biological names infered from orthology : DEAF1, transcription factor / O75398
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 141297180
Gene end: 141327690
  
Corresponding Affymetrix probe sets: 10569134 (MoGene1.0st)   1448446_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147326
Ensembl peptide - ENSMUSP00000079395
Ensembl peptide - ENSMUSP00000147576
Ensembl peptide - ENSMUSP00000148149
Ensembl peptide - ENSMUSP00000148125
Ensembl peptide - ENSMUSP00000147786
Ensembl peptide - ENSMUSP00000147728
Ensembl peptide - ENSMUSP00000147631
Ensembl peptide - ENSMUSP00000147600
NCBI entrez gene - 54006     See in Manteia.
MGI - MGI:1858496
RefSeq - XM_017322370
RefSeq - NM_016874
RefSeq - XM_006536204
RefSeq - XM_006536205
RefSeq - XM_006536206
RefSeq - XM_006536207
RefSeq - XM_006536208
RefSeq - XM_006536209
RefSeq - XM_006536210
RefSeq - XM_006536211
RefSeq - XM_006536212
RefSeq - XM_006536213
RefSeq - XM_017322368
RefSeq - XM_017322369
RefSeq - NM_001282072
RefSeq - NM_001282073
RefSeq - NM_001282076
RefSeq Peptide - NP_001269005
RefSeq Peptide - NP_058570
RefSeq Peptide - NP_001269001
RefSeq Peptide - NP_001269002
swissprot - A0A1B0GRR4
swissprot - A0A1B0GRN9
swissprot - A0A1B0GT08
swissprot - Q9Z1T5
swissprot - A0A1B0GR05
swissprot - A0A1B0GRL7
swissprot - A0A1B0GSY7
swissprot - A0A1B0GS42
swissprot - A0A1B0GRZ5
Ensembl - ENSMUSG00000058886
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 deaf1ENSDARG00000088844Danio rerio
 DEAF1ENSGALG00000034225Gallus gallus
 DEAF1ENSG00000177030Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O54972 / Cbfa2t3 / Protein CBFA2T3 / O75081* / CBFA2/RUNX1 translocation partner 3*ENSMUSG0000000636217
Q61909 / Runx1t1 / runt-related transcription factor 1; translocated to, 1 (cyclin D-related) / Q06455* / RUNX1 translocation partner 1*ENSMUSG0000000658617
O70374 / Cbfa2t2 / core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) / O43439* / CBFA2/RUNX1 translocation partner 2*ENSMUSG0000003853315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000770  SAND domain
 IPR002893  Zinc finger, MYND-type
 IPR010919  SAND-like domain superfamily
 IPR024119  Transcription factor DEAF-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001662 behavioral fear response IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008542 visual learning IMP
 biological_processGO:0033599 regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048706 embryonic skeletal system development IMP
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000153 rib bifurcation "forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Deaf1tm1Sho/Deaf1+
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Deaf1tm1Sho/Deaf1+
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lmo4tm2Sho/Lmo4tm2Sho
Genetic Background: either: (involves: 129/Sv * CD-1) or (involves: 129/Sv * C57BL/6)

 MP:0012306 enhanced spatial learning "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Ntrk2tm1Mini/Ntrk2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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