ENSMUSG00000006586


Mus musculus

Features
Gene ID: ENSMUSG00000006586
  
Biological name :Runx1t1
  
Synonyms : Q61909 / runt-related transcription factor 1; translocated to, 1 (cyclin D-related) / Runx1t1
  
Possible biological names infered from orthology : Q06455 / RUNX1 translocation partner 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 13743436
Gene end: 13893649
  
Corresponding Affymetrix probe sets: 10503382 (MoGene1.0st)   1427640_a_at (Mouse Genome 430 2.0 Array)   1437784_at (Mouse Genome 430 2.0 Array)   1440310_at (Mouse Genome 430 2.0 Array)   1443788_at (Mouse Genome 430 2.0 Array)   1444615_x_at (Mouse Genome 430 2.0 Array)   1448785_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127109
Ensembl peptide - ENSMUSP00000006761
Ensembl peptide - ENSMUSP00000095856
Ensembl peptide - ENSMUSP00000095857
NCBI entrez gene - 12395     See in Manteia.
MGI - MGI:104793
RefSeq - XM_011249912
RefSeq - NM_001111027
RefSeq - NM_009822
RefSeq - XM_006537568
RefSeq - XM_006537569
RefSeq - XM_006537571
RefSeq - XM_006537572
RefSeq - XM_011249911
RefSeq - NM_001111026
RefSeq Peptide - NP_001104496
RefSeq Peptide - NP_001104497
RefSeq Peptide - NP_033952
swissprot - B1AXH9
swissprot - B1AXH8
swissprot - Q3UQX8
swissprot - Q61909
Ensembl - ENSMUSG00000006586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 runx1t1ENSDARG00000003680Danio rerio
 RUNX1T1ENSGALG00000033091Gallus gallus
 Q06455ENSG00000079102Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O54972 / Cbfa2t3 / Protein CBFA2T3 / O75081* / CBFA2/RUNX1 translocation partner 3*ENSMUSG0000000636271
O70374 / Cbfa2t2 / core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) / O43439* / CBFA2/RUNX1 translocation partner 2*ENSMUSG0000003853361
Deaf1 / Q9Z1T5 / Deformed epidermal autoregulatory factor 1 homolog / O75398* / DEAF1, transcription factor*ENSMUSG0000005888616


Protein motifs (from Interpro)
Interpro ID Name
 IPR002893  Zinc finger, MYND-type
 IPR003894  TAFH/NHR1
 IPR013289  CBFA2T family
 IPR013290  Protein CBFA2T1
 IPR014896  NHR2-like
 IPR037249  TAFH/NHR1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0010977 negative regulation of neuron projection development ISS
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0051101 regulation of DNA binding IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016363 nuclear matrix ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000492 abnormal rectum morphology "structural aberration in the terminal portion of the intestinal tube adjacent to the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Runx1tm1Buch/Runx1tm1Buch
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Runx1t1tm1Buch/Runx1t1+,Runx1tm1Buch/Runx1+,Tg(Nes-cre)1Atp/0
Genetic Background: involves: FVB/N

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008108 abnormal small intestinal villus morphology "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009706 absent midgut "absence of the portion of the embryonic gut between the foregut and the hindgut" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Runx1t1tm1Fc/Runx1t1+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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