ENSMUSG00000006362


Mus musculus

Features
Gene ID: ENSMUSG00000006362
  
Biological name :Cbfa2t3
  
Synonyms : Cbfa2t3 / O54972 / Protein CBFA2T3
  
Possible biological names infered from orthology : CBFA2/RUNX1 translocation partner 3 / O75081
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 122625141
Gene end: 122699109
  
Corresponding Affymetrix probe sets: 10582427 (MoGene1.0st)   10582429 (MoGene1.0st)   1418582_at (Mouse Genome 430 2.0 Array)   1438705_at (Mouse Genome 430 2.0 Array)   1440963_at (Mouse Genome 430 2.0 Array)   1440964_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117630
Ensembl peptide - ENSMUSP00000118997
Ensembl peptide - ENSMUSP00000006525
Ensembl peptide - ENSMUSP00000065728
NCBI entrez gene - 12398     See in Manteia.
MGI - MGI:1338013
RefSeq - XM_017312549
RefSeq - XM_011248291
RefSeq - XM_011248292
RefSeq - XM_011248293
RefSeq - XM_017312544
RefSeq - XM_017312545
RefSeq - XM_017312547
RefSeq - XM_017312548
RefSeq - NM_001109873
RefSeq - NM_009824
RefSeq - NM_177289
RefSeq - XM_011248289
RefSeq Peptide - NP_796263
RefSeq Peptide - NP_001103343
RefSeq Peptide - NP_033954
swissprot - B7ZP57
swissprot - O54972
swissprot - D3Z3P7
swissprot - E9QM80
Ensembl - ENSMUSG00000006362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cbfa2t3ENSDARG00000079012Danio rerio
 CBFA2T3ENSGALG00000032410Gallus gallus
 O75081ENSG00000129993Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61909 / Runx1t1 / runt-related transcription factor 1; translocated to, 1 (cyclin D-related) / Q06455* / RUNX1 translocation partner 1*ENSMUSG0000000658669
O70374 / Cbfa2t2 / core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) / O43439* / CBFA2/RUNX1 translocation partner 2*ENSMUSG0000003853357
Deaf1 / Q9Z1T5 / Deformed epidermal autoregulatory factor 1 homolog / O75398* / DEAF1, transcription factor*ENSMUSG0000005888615


Protein motifs (from Interpro)
Interpro ID Name
 IPR002893  Zinc finger, MYND-type
 IPR003894  TAFH/NHR1
 IPR013289  CBFA2T family
 IPR013292  Protein CBFA2T3
 IPR014896  NHR2-like
 IPR037249  TAFH/NHR1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030851 granulocyte differentiation ISO
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0045820 negative regulation of glycolytic process ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1903715 regulation of aerobic respiration ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0002413 abnormal megakaryoblast morphology/development "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

 MP:0010178 increased number of Howell-Jolly bodies "abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ArTfm/Y
Genetic Background: involves: NMRI * STOCK EdaTa Atp7aMo-blo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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