ENSMUSG00000058914


Mus musculus

Features
Gene ID: ENSMUSG00000058914
  
Biological name :C1qtnf3
  
Synonyms : C1qtnf3 / Complement C1q tumor necrosis factor-related protein 3 / Q9ES30
  
Possible biological names infered from orthology : C1q and TNF related 3 / C1QTNF3-AMACR / C1QTNF3-AMACR readthrough (NMD candidate) / Q9BXJ4
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: A1
Gene start: 10952332
Gene end: 10980150
  
Corresponding Affymetrix probe sets: 10423080 (MoGene1.0st)   1422606_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022853
Ensembl peptide - ENSMUSP00000106152
NCBI entrez gene - 81799     See in Manteia.
MGI - MGI:1932136
RefSeq - NM_001204134
RefSeq - NM_030888
RefSeq Peptide - NP_001191063
RefSeq Peptide - NP_112150
swissprot - Q9ES30
swissprot - Q4ZJN6
swissprot - D3YZ61
Ensembl - ENSMUSG00000058914
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000027887Gallus gallus
 C1QTNF3-AMACRENSG00000273294Homo sapiens
 Q9BXJ4ENSG00000082196Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q05A80 / Caprin2 / Q6IMN6* / caprin family member 2*ENSMUSG0000003030924
C1ql2 / Q8CFR0 / Complement C1q-like protein 2 / Q7Z5L3* / complement C1q like 2*ENSMUSG0000003690720
C1ql3 / Q9ESN4 / Complement C1q-like protein 3 / Q5VWW1* / complement C1q like 3*ENSMUSG0000004963019
Cbln2 / Q8BGU2 / Cerebellin-2 / Q8IUK8* / cerebellin 2 precursor*ENSMUSG0000002464719
Cbln4 / Q8BME9 / Cerebellin-4 / Q9NTU7* / cerebellin 4 precursor*ENSMUSG0000006757819
Cbln3 / Q9JHG0 / Cerebellin-3 / Q6UW01* / cerebellin 3 precursor*ENSMUSG0000004038019
Cbln1 / Q9R171 / Cerebellin-1 Cerebellin [des-Ser1]-cerebellin / P23435* / cerebellin 1 precursor*ENSMUSG0000003165419
C1ql1 / O88992 / C1q-related factor / O75973* / complement C1q like 1*ENSMUSG0000004553218
C1ql4 / Q4ZJM9 / Complement C1q-like protein 4 / Q86Z23* / complement C1q like 4*ENSMUSG0000000107618
Q60865 / Caprin1 / Q14444* / cell cycle associated protein 1*ENSMUSG0000002718411


Protein motifs (from Interpro)
Interpro ID Name
 IPR001073  C1q domain
 IPR008160  Collagen triple helix repeat
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR016133  Insect cysteine-rich antifreeze protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0035356 cellular triglyceride homeostasis ISO
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0045721 negative regulation of gluconeogenesis ISO
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050728 negative regulation of inflammatory response ISO
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0070165 positive regulation of adiponectin secretion ISO
 biological_processGO:0070206 protein trimerization ISO
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071638 negative regulation of monocyte chemotactic protein-1 production ISO
 biological_processGO:1900165 negative regulation of interleukin-6 secretion ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Rab8atm1.2Aha/Rab8atm1.2Aha
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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