ENSMUSG00000059022


Mus musculus

Features
Gene ID: ENSMUSG00000059022
  
Biological name :Kcp
  
Synonyms : Kcp / Kielin/chordin-like protein / Q3U492
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: A3.3
Gene start: 29473162
Gene end: 29507952
  
Corresponding Affymetrix probe sets: 10543600 (MoGene1.0st)   1440955_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125699
Ensembl peptide - ENSMUSP00000124771
Ensembl peptide - ENSMUSP00000125716
Ensembl peptide - ENSMUSP00000077251
Ensembl peptide - ENSMUSP00000088954
Ensembl peptide - ENSMUSP00000099135
Ensembl peptide - ENSMUSP00000124097
NCBI entrez gene - 333088     See in Manteia.
MGI - MGI:2141640
RefSeq - XM_017321663
RefSeq - XM_006505131
RefSeq - XM_006505134
RefSeq - XM_011241070
RefSeq - XM_011241071
RefSeq - XM_017321660
RefSeq - XM_017321661
RefSeq - XM_017321662
RefSeq - NM_001029985
RefSeq Peptide - NP_001025156
swissprot - F7B5X1
swissprot - F7DED4
swissprot - F6UH68
swissprot - E0CYL0
swissprot - Q3U492
swissprot - E9QNB3
Ensembl - ENSMUSG00000059022
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-266m15.6ENSDARG00000078508Danio rerio
 KCPENSG00000135253Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vwce / Q3U515 / von Willebrand factor C and EGF domains / Q96DN2*ENSMUSG0000004378915
Bmper / Q8CJ69 / BMP-binding endothelial regulator protein / Q8N8U9* / BMP binding endothelial regulator*ENSMUSG0000003196315
Crim1 / Q9JLL0 / Cysteine-rich motor neuron 1 protein / Q9NZV1* / cysteine rich transmembrane BMP regulator 1*ENSMUSG0000002407414


Protein motifs (from Interpro)
Interpro ID Name
 IPR001007  VWFC domain
 IPR001846  von Willebrand factor, type D domain
 IPR014853  Uncharacterised domain, cysteine-rich
 IPR036084  Serine protease inhibitor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0030513 positive regulation of BMP signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmpertm1Ysas/Bmpertm1Ysas,Kcptm1Ysas/Kcptm1Ysas
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Bmpertm1Ysas/Bmpertm1Ysas,Kcptm1Ysas/Kcp+
Genetic Background: involves: C57BL/6 * CBA

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0003639 abnormal response to vitamins "altered ability or inability to respond to or metabolize a group of organic substances that are required in trace amounts for the normal metabolic homeostasis of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmpertm1Ysas/Bmpertm1Ysas,Kcptm1Ysas/Kcptm1Ysas
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Bmpertm1Ysas/Bmpertm1Ysas,Kcptm1Ysas/Kcp+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmp4tm2Blh/Bmp4+,Bmpertm1Ysas/Bmper+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sod1tm1Leb/Sod1+
Genetic Background: B6;129S-Sod1tm1Leb/J

 MP:0011376 abnormal kidney corticomedullary boundary morphology "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna]
Show

Allelic Composition: Bmpertm1Ysas/Bmpertm1Ysas,Kcptm1Ysas/Kcptm1Ysas
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Bmpertm1Ysas/Bmpertm1Ysas,Kcptm1Ysas/Kcp+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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