| MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000522 | cysts in kidney cortex | "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000523 | cortical glomerulopathies | "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0000564 | syndactyly | "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1tm1.1Dpen/Crim1tm1.1Dpen
Genetic Background: either: (B6.129P2(129S7)-Crim1tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
|
| MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Crim1tm1.1Dpen/Crim1tm1.1Dpen
Genetic Background: either: (B6.129P2(129S7)-Crim1tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
|
| MP:0001306 | small lens | "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Crim1tm1Dpen/Crim1tm1Dpen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0001859 | kidney inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Nos3tm1.2Taka/Nos3tm1.2Taka
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA
Allelic Composition: Crim1tm1Dpen/Crim1tm1Dpen
Genetic Background: B6.129P2-Crim1tm1Dpen
Allelic Composition: Crim1tm1Dpen/Crim1tm1Dpen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0002705 | dilated renal tubules | "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0002871 | albuminuria | "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0002989 | small kidney | "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0003070 | increased vascular permeability | "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0003215 | renal interstitial fibrosis | "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0003446 | renal hypoplasia | "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Crim1tm1.1Dpen/Crim1tm1.1Dpen
Genetic Background: either: (B6.129P2(129S7)-Crim1tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
|
| MP:0004154 | renal tubular necrosis | "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0004194 | abnormal kidney pelvis morphology | "any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0004269 | abnormal optic cup morphology | "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0004273 | abnormal basal lamina morphology | "anomaly in the structure of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0005264 | glomerulosclerosis | "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0005299 | abnormal eye posterior chamber | "anomaly of the ringlike space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Crim1tm1.1Dpen/Crim1tm1.1Dpen
Genetic Background: either: (B6.129P2(129S7)-Crim1tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0005326 | abnormal podocytes | "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0005528 | decreased glomerular filtration rate | "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0005556 | abnormal kidney clearance | "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0005581 | abnormal renin activity | "alterated ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0008059 | abnormal podocyte foot process morphology | "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0008140 | podocyte foot process effacement | "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0008817 | hematoma | "an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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| MP:0008854 | bleb | "presence of a blister-like, nearly hemispherical structure formed during embryonic development filled with air, serous fluid or blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Crim1tm1.1Dpen/Crim1tm1.1Dpen
Genetic Background: either: (B6.129P2(129S7)-Crim1tm1.1Dpen) or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CD-1)
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| MP:0008856 | fetal bleb | "presence of subepidermal blister-like structures on the skin, often on the head, formed during embryonic development and usually filled with blood" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0010831 | partial lethality | "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Crim1tm1Dpen/Crim1tm1Dpen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Crim1tm1Dpen/Crim1tm1Dpen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011294 | renal glomerulus hypertrophy | "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011304 | kidney papillary atrophy | "acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011320 | abnormal glomerular capillary morphology | "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0011321 | abnormal peritubular capillary morphology | "any structural anomaly of the tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure" [MGI:csmith] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011348 | abnormal renal glomerulus basement membrane morphology | "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0011368 | increased kidney apoptosis | "increase in the number of cells of the kidney undergoing programmed cell death" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011376 | abnormal kidney corticomedullary boundary morphology | "any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011409 | increased renal glomerulus basement membrane thickness | "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0011430 | mesangiolysis | "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
|
| MP:0011437 | glomerulus hemorrhage | "bleeding in the renal glomerulus" [MGI:anna] |
Show
Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0011453 | abnormal glomerular capillary endothelium morphology | "any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms" [MGI:anna] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011455 | absent glomerular endothelium fenestra | "absence of the large plasma membrane-lined circular pores that normally perforate the flattened glomerular endothelium; loss of fenestrae may lead to a reduction in the glomerular filtration rate or proteinuria" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011480 | impaired ureteric peristalsis | "any anomaly in the wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, thus propelling urine from the kidney pelvis to the urinary bladder" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011501 | increased glomerular capsule space | "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011509 | dilated glomerular capillary | "stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole" [MGI:anna] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Crim1Gt(KST264)Byg/Crim1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011565 | kidney papillary hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the apex of the renal pyramid that normally projects into a calyx" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0011682 | renal glomerulus cysts | "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011753 | decreased podocyte number | "reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle" [MGI:anna] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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| MP:0011854 | cerebral edema | "excess accumulation of water in the intra- and/or extracellular spaces of the brain" [MGI:anna] |
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Allelic Composition: Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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| MP:0011856 | abnormal glomerular filtration barrier function | "anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman s space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011857 | short kidney papilla | "reduced average length of the apex of the renal pyramid that projects into a calyx" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011859 | decreased renal glomerulus basement membrane thickness | "reduced width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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| MP:0011860 | abnormal peritubular capillary endothelium morphology | "any structural anomaly of the thin sheet of endothelial cells along the basal lamina of renal tubular cells characterized by their attenuated shape and numerous regularly-spaced transcellular pores (aka fenestrae or fenestrations); the fenestrae of peritubular capillaries differ from the fenestrae of glomerular capillaries in that they are much smaller and possess a small overlying diaphragm" [MGI:anna] |
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Allelic Composition: Crim1Gt(KST264)Byg/Crim1Gt(KST264)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
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