ENSMUSG00000059586


Mus musculus

Features
Gene ID: ENSMUSG00000059586
  
Biological name :Nsmce2
  
Synonyms : E3 SUMO-protein ligase NSE2 / Nsmce2 / Q91VT1
  
Possible biological names infered from orthology : NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase / Q96MF7
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D1
Gene start: 59374247
Gene end: 59601684
  
Corresponding Affymetrix probe sets: 10424363 (MoGene1.0st)   1424149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078641
Ensembl peptide - ENSMUSP00000128893
Ensembl peptide - ENSMUSP00000154811
NCBI entrez gene - 68501     See in Manteia.
MGI - MGI:1915751
RefSeq - XM_017316737
RefSeq - NM_001164604
RefSeq - NM_026746
RefSeq - XM_006521316
RefSeq - XM_006521317
RefSeq Peptide - NP_001158076
RefSeq Peptide - NP_081022
swissprot - Q91VT1
Ensembl - ENSMUSG00000059586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nsmce2ENSDARG00000076379Danio rerio
 NSMCE2ENSGALG00000043439Gallus gallus
 NSMCE2ENSG00000156831Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003613  U box domain
 IPR004181  Zinc finger, MIZ-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR026846  E3 SUMO-protein ligase Nse2 (Mms21)


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000722 telomere maintenance via recombination IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination ISS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016925 protein sumoylation IEA
 biological_processGO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion IEA
 biological_processGO:0045842 positive regulation of mitotic metaphase/anaphase transition IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090398 cellular senescence IEA
 cellular_componentGO:0000781 chromosome, telomeric region ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0030915 Smc5-Smc6 complex ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019789 SUMO transferase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003701 elevated level of sister chromatid exchange "increased number of crossovers between sister chromatids during meiosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:97667]
Show

Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0003707 increased nucleus count "greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
Show

Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003902 abnormal cell mass "anomaly in the total physical bulk or volume of a cell compared to the normal state" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Blmtm4Ches/Blmtm4Ches,Cd19tm1(cre)Cgn/Cd19+,Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006204 embryonic lethality before implantation "death anytime after fertilization but before implantation (E0 to less than E4.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cdk12tm1.1Mjfn/Cdk12tm1.2Mjfn,Sox2tm1Rlb/Sox2+
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
Show

Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009567 mitotic nondisjuction "failure of sister-chromatids to separate to the cell poles at anaphase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nsmce2tm2.1Ofc/Nsmce2tm2.1Ofc,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0010291 increased cardiovascular system tumor incidence "greater than the expected number of tumors originating in the cardiovascular system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Nsmce2Gt(AA0032)Wtsi/Nsmce2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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