ENSMUSG00000060548


Mus musculus

Features
Gene ID: ENSMUSG00000060548
  
Biological name :Tnfrsf19
  
Synonyms : Q9JLL3 / Tnfrsf19 / Tumor necrosis factor receptor superfamily member 19
  
Possible biological names infered from orthology : Q9NS68 / TNF receptor superfamily member 19
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 60963875
Gene end: 61046490
  
Corresponding Affymetrix probe sets: 10420596 (MoGene1.0st)   1415921_a_at (Mouse Genome 430 2.0 Array)   1425212_a_at (Mouse Genome 430 2.0 Array)   1448147_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106865
Ensembl peptide - ENSMUSP00000106867
Ensembl peptide - ENSMUSP00000152920
Ensembl peptide - ENSMUSP00000153577
NCBI entrez gene - 29820     See in Manteia.
MGI - MGI:1352474
RefSeq - NM_001164155
RefSeq - NM_013869
RefSeq Peptide - NP_001157627
RefSeq Peptide - NP_038897
swissprot - Q9JLL3
Ensembl - ENSMUSG00000060548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfrsf19ENSDARG00000041869Danio rerio
 TNFRSF19ENSGALG00000017119Gallus gallus
 Q9NS68ENSG00000127863Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eda2r / Q8BX35 / Tumor necrosis factor receptor superfamily member 27 / Q9HAV5* / ectodysplasin A2 receptor*ENSMUSG0000003445724


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR022342  Tumour necrosis factor receptor 19
 IPR034047  Tumor necrosis factor receptor 19, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001942 hair follicle development IGI
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0046330 positive regulation of JNK cascade IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000125 absent incisors "missing long pointed teeth; most anterior and prominent in the jaw" [J:17489]
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Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0000400 abnormal awl hair "anomalies of truncal hairs that contain two or more air cells in the medulla" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
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Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Plxna3tm1Matl/Y,Plxna4tm1Matl/Plxna4tm1Matl
Genetic Background: either: (involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6) or (involves: 129P2/OlaHsd * 129S1/Sv * CD-1)

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0006363 absent auchene hairs "absence of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0006365 absent guard hair "absence of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0006366 absent zigzag hairs "absence of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0006367 absent sweat gland "absence of any of the coil glands of the skin that secrete sweat" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0006400 decreased molar number "reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0013370 anhidrosis "complete absence of sweating in response to appropriate stimuli" [MGI:Anna]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

 MP:0030457 abnormal molar cusp morphology "any structural anomaly of an elevation or mound on the crown of a molar tooth making up a part of the occlusal (masticatory) surface" [https://medical-dictionary.thefreedictionary.com/cusp+of+tooth, MGI:anna]
Show

Allelic Composition: EdaTa/EdaTa,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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