ENSMUSG00000063694


Mus musculus

Features
Gene ID: ENSMUSG00000063694
  
Biological name :Cycs
  
Synonyms : Cycs / Cytochrome c, somatic / P62897
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B2.3
Gene start: 50562563
Gene end: 50566538
  
Corresponding Affymetrix probe sets: 10462136 (MoGene1.0st)   10528170 (MoGene1.0st)   10544687 (MoGene1.0st)   1422483_a_at (Mouse Genome 430 2.0 Array)   1422484_at (Mouse Genome 430 2.0 Array)   1445484_at (Mouse Genome 430 2.0 Array)   1456071_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124523
NCBI entrez gene - 13063     See in Manteia.
MGI - MGI:88578
RefSeq - NM_007808
RefSeq Peptide - NP_031834
swissprot - P62897
swissprot - Q56A15
Ensembl - ENSMUSG00000063694
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cycsaENSDARG00000095636Danio rerio
 CYCSENSGALG00000011020Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P62897 / Gm10053 / predicted gene 10053ENSMUSG00000058927100
Cyct / P00015 / Cytochrome c, testis-specific ENSMUSG0000005643687


Protein motifs (from Interpro)
Interpro ID Name
 IPR002327  Cytochrome c, class IA/ IB
 IPR009056  Cytochrome c-like domain
 IPR036909  Cytochrome c-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c IBA
 biological_processGO:0006123 mitochondrial electron transport, cytochrome c to oxygen IBA
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0042743 hydrogen peroxide metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0070469 respiratory chain IEA
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000238 deficiency of pre-B cells "lack of progenitor cells that form the B cell component of the immune system" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000898 midbrain hyperplasia "increased cell number associated with the middle of the three cerebral vesicles of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0000919 cranioschisis "incomplete closure of the skull, usually congenital " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001395 bi-directional circling "circling behavior exhibited in both clockwise and counterclockwise directions" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0001916 intracerebral hemorrhage "bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Map2k4tm1Lizon/Map2k4tm1Lizon
Genetic Background: involves: 129S1/Sv

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0020527 small thalamus "decreased size of the thalamus" [MGI:smb]
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Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

 MP:0030049 prominent forehead "forward prominence of the entire forehead, due to protrusion of the frontal bone; not to be confused with frontal bossing" [HP:0011220]
Show

Allelic Composition: Rbl2tm1Mru/Rbl2tm1Mru
Genetic Background: involves: 129S4/SvJae * BALB/cJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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