ENSMUSG00000064158


Mus musculus

Features
Gene ID: ENSMUSG00000064158
  
Biological name :Izumo1
  
Synonyms : Izumo1 / Izumo sperm-egg fusion protein 1 / Q9D9J7
  
Possible biological names infered from orthology : izumo sperm-egg fusion 1 / Q8IYV9
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B3
Gene start: 45621811
Gene end: 45628823
  
Corresponding Affymetrix probe sets: 10553031 (MoGene1.0st)   1429695_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033100
NCBI entrez gene - 73456     See in Manteia.
MGI - MGI:1920706
RefSeq - XM_017312333
RefSeq - NM_001018013
RefSeq - XM_006541222
RefSeq Peptide - NP_001018013
swissprot - Q9D9J7
Ensembl - ENSMUSG00000064158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 izumo1ENSDARG00000116848Danio rerio
 IZUMO1ENSG00000182264Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013783  Immunoglobulin-like fold
 IPR029389  Izumo sperm-egg fusion protein
 IPR032699  Izumo protein, immunoglobulin domain
 IPR032700  Izumo sperm-egg fusion protein 1
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IC
 biological_processGO:0007338 single fertilization IMP
 biological_processGO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization IDA
 biological_processGO:0034113 heterotypic cell-cell adhesion IMP
 biological_processGO:0035036 sperm-egg recognition IMP
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0002080 acrosomal membrane IDA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0086080 protein binding involved in heterotypic cell-cell adhesion IMP


Pathways (from Reactome)
Pathway description
Sperm:Oocyte Membrane Binding


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tnfsf4Ath1-PERA/EiJ/Tnfsf4Ath1-PERA/EiJ
Genetic Background: B6.PERA-Tnfsf4Ath1-PERA/EiJ/Pgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030342 Cd9 / P40240 / CD9 antigen / P21926* / CD9 molecule*  / reaction / complex






 

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