ENSMUSG00000064210


Mus musculus

Features
Gene ID: ENSMUSG00000064210
  
Biological name :Ano6
  
Synonyms : Ano6 / Anoctamin-6 / Q6P9J9
  
Possible biological names infered from orthology : Q4KMQ2
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E3
Gene start: 95790843
Gene end: 95974751
  
Corresponding Affymetrix probe sets: 10426479 (MoGene1.0st)   1455308_at (Mouse Genome 430 2.0 Array)   1455309_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071770
Ensembl peptide - ENSMUSP00000153853
Ensembl peptide - ENSMUSP00000153954
Ensembl peptide - ENSMUSP00000154532
NCBI entrez gene - 105722     See in Manteia.
MGI - MGI:2145890
RefSeq - XM_006520234
RefSeq - NM_001253813
RefSeq - NM_175344
RefSeq - XM_006520231
RefSeq - XM_006520232
RefSeq - XM_006520233
RefSeq Peptide - NP_780553
RefSeq Peptide - NP_001240742
swissprot - Q6P9J9
Ensembl - ENSMUSG00000064210
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ano6ENSDARG00000061544Danio rerio
 ANO6ENSGALG00000009638Gallus gallus
 ANO6ENSG00000177119Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ano5 / Q75UR0 / Anoctamin-5 / Q75V66*ENSMUSG0000005548947
Ano4 / Q8C5H1 / Anoctamin-4 / Q32M45*ENSMUSG0000003518943
Ano3 / A2AHL1 / Anoctamin-3 / Q9BYT9*ENSMUSG0000007496841
Ano1 / Q8BHY3 / Anoctamin-1 / Q5XXA6*ENSMUSG0000003107536
Ano2 / Q8CFW1 / Anoctamin-2 / Q9NQ90*ENSMUSG0000003811536
Ano7 / Q14AT5 / Anoctamin-7 / Q6IWH7*ENSMUSG0000003410733
Ano9 / P86044 / Anoctamin-9 / A1A5B4*ENSMUSG0000005466227
Ano8 / Q6PB70 / Anoctamin-8 / Q9HCE9*ENSMUSG0000003486320
Ano10 / Q8BH79 / Anoctamin-10 / Q9NW15*ENSMUSG0000003794918


Protein motifs (from Interpro)
Interpro ID Name
 IPR007632  Anoctamin
 IPR031295  Anoctamin-6
 IPR032394  Anoctamin, dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002407 dendritic cell chemotaxis IEA
 biological_processGO:0002543 activation of blood coagulation via clotting cascade IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006821 chloride transport ISO
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0017121 phospholipid scrambling IMP
 biological_processGO:0030501 positive regulation of bone mineralization IEA
 biological_processGO:0032060 bleb assembly IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0034767 positive regulation of ion transmembrane transport IEA
 biological_processGO:0035590 purinergic nucleotide receptor signaling pathway IMP
 biological_processGO:0035630 bone mineralization involved in bone maturation IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045794 negative regulation of cell volume IMP
 biological_processGO:0046931 pore complex assembly IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IMP
 biological_processGO:0061588 calcium activated phospholipid scrambling IEA
 biological_processGO:0061589 calcium activated phosphatidylserine scrambling IDA
 biological_processGO:0061590 calcium activated phosphatidylcholine scrambling IDA
 biological_processGO:0061591 calcium activated galactosylceramide scrambling IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 biological_processGO:0097045 phosphatidylserine exposure on blood platelet IEA
 biological_processGO:1902304 positive regulation of potassium ion export IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034707 chloride channel complex ISO
 molecular_functionGO:0005227 calcium activated cation channel activity IEA
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity IMP
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005247 voltage-gated chloride channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0017128 phospholipid scramblase activity IMP
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004672 short ribs "reduced length of the bones forming the bony wall of the chest" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
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Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

Allelic Composition: Ano6tm1Avor/Ano6tm1Avor
Genetic Background: involves: 129

 MP:0009445 osteomalacia "gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010926 increased osteoid volume "increase in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0010929 increased osteoid thickness "increase in the width of the layer of newly formed organic bone matrix secreted by osteoblasts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020138 delayed bone mineralization "late onset of the process by which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030029 wide cranial sutures "an abnormally increased width of one or more cranial sutures for age-related norms, generally resulting from delayed suture closure" [HP:0010537]
Show

Allelic Composition: Batf3tm1Kmm/Batf3tm1Kmm,Id2tm1Gtbz/Id2tm1Gtbz
Genetic Background: B6.Cg-Batf3tm1Kmm Id2tm1Gtbz

Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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