ENSMUSG00000031075


Mus musculus

Features
Gene ID: ENSMUSG00000031075
  
Biological name :Ano1
  
Synonyms : Ano1 / Anoctamin-1 / Q8BHY3
  
Possible biological names infered from orthology : Q5XXA6
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F5
Gene start: 144588549
Gene end: 144751974
  
Corresponding Affymetrix probe sets: 10569618 (MoGene1.0st)   1426571_at (Mouse Genome 430 2.0 Array)   1459495_at (Mouse Genome 430 2.0 Array)   1459713_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118206
Ensembl peptide - ENSMUSP00000113899
Ensembl peptide - ENSMUSP00000119653
Ensembl peptide - ENSMUSP00000120306
Ensembl peptide - ENSMUSP00000033393
Ensembl peptide - ENSMUSP00000112616
NCBI entrez gene - 101772     See in Manteia.
MGI - MGI:2142149
RefSeq - XM_017321913
RefSeq - XM_006508458
RefSeq - XM_006508459
RefSeq - XM_006508463
RefSeq - XM_006508464
RefSeq - XM_011241973
RefSeq - XM_011241974
RefSeq - XM_011241975
RefSeq - XM_011241976
RefSeq - NM_001242349
RefSeq - NM_178642
RefSeq Peptide - NP_001229278
RefSeq Peptide - NP_848757
swissprot - G8JL82
swissprot - D3YYA4
swissprot - D3Z035
swissprot - A0A0A0MQF2
swissprot - Q8BHY3
swissprot - F6R6E1
Ensembl - ENSMUSG00000031075
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ano1ENSDARG00000102335Danio rerio
 ANO1ENSGALG00000041808Gallus gallus
 ANO1ENSG00000131620Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ano2 / Q8CFW1 / Anoctamin-2 / Q9NQ90*ENSMUSG0000003811556
Ano4 / Q8C5H1 / Anoctamin-4 / Q32M45*ENSMUSG0000003518937
Ano3 / A2AHL1 / Anoctamin-3 / Q9BYT9*ENSMUSG0000007496835
Ano5 / Q75UR0 / Anoctamin-5 / Q75V66*ENSMUSG0000005548933
Ano6 / Q6P9J9 / Anoctamin-6 / Q4KMQ2*ENSMUSG0000006421032
Ano7 / Q14AT5 / Anoctamin-7 / Q6IWH7*ENSMUSG0000003410731
Ano9 / P86044 / Anoctamin-9 / A1A5B4*ENSMUSG0000005466223
Ano8 / Q6PB70 / Anoctamin-8 / Q9HCE9*ENSMUSG0000003486316
Ano10 / Q8BH79 / Anoctamin-10 / Q9NW15*ENSMUSG0000003794914


Protein motifs (from Interpro)
Interpro ID Name
 IPR007632  Anoctamin
 IPR031287  Anoctamin-1
 IPR032394  Anoctamin, dimerisation domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport ISO
 biological_processGO:0006821 chloride transport ISO
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0015705 iodide transport ISO
 biological_processGO:0034605 cellular response to heat IDA
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IMP
 biological_processGO:0060438 trachea development IMP
 biological_processGO:1902476 chloride transmembrane transport ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0034707 chloride channel complex IEA
 molecular_functionGO:0005227 calcium activated cation channel activity ISO
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity ISO
 molecular_functionGO:0005247 voltage-gated chloride channel activity IDA
 molecular_functionGO:0005254 chloride channel activity ISO
 molecular_functionGO:0015111 iodide transmembrane transporter activity ISO
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000249 abnormal blood vessel physiology "anomalous function of any of the tubes that convey blood: arteries, arterioles, capallaries, venules, veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0000965 abnormal sensory neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of sensory impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Ano1tm1.1Jwo/Ano1tm1.1Jwo,Aviltm2(cre)Fawa/Avil+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Stard13tm1.2Fms/Stard13tm1.2Fms
Genetic Background: involves: BALB/cJ * C57BL/6 * SJL

 MP:0002282 abnormal trachea morphology "structral anomaly of the tube descending from the larynx and branching into the right and left main bronchi" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0002284 abnormal tracheal smooth muscle morphology "structural anomaly of the smooth muscle lining the trachea" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0002285 abnormal tracheal ciliated epithelium morphology "structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0003719 abnormal pericyte morphology "malformation in the connective tissue cells that occurs around capillaries or other small blood vessels " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdtm1.1Know/Dmdtm1.1Know,Tg(Myh6-2A)#Know/0,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0010988 abnormal bronchial cartilage morphology "any structural anomaly of the hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0010994 aerophagia "excessive swallowing of air or gas" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Rps6ka4tm1Jsca/Rps6ka4tm1Jsca,Rps6ka5tm1Jsca/Rps6ka5tm1Jsca
Genetic Background: B6.Cg-Il10tm1Cgn Rps6ka5tm1Jsca Rps6ka4tm1Jsca

Allelic Composition: Ano1tm1.2Cahb/Ano1tm1.2Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
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Allelic Composition: Ano1tm2Jrr/Ano1tm2Jrr,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S6/SvEvTac * ICR

 MP:0014208 decreased intestinal epithelial chloride transmembrane transport 
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Allelic Composition: Col2a1Rgsc413/Col2a1Rgsc413
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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