ENSMUSG00000064246


Mus musculus

Features
Gene ID: ENSMUSG00000064246
  
Biological name :Chil1
  
Synonyms : Chil1 / Chitinase-3-like protein 1 / Q61362
  
Possible biological names infered from orthology : CHI3L1 / chitinase 3 like 1 / P36222
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: E4
Gene start: 134182176
Gene end: 134190181
  
Corresponding Affymetrix probe sets: 10349968 (MoGene1.0st)   1451537_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118289
Ensembl peptide - ENSMUSP00000121471
Ensembl peptide - ENSMUSP00000119205
Ensembl peptide - ENSMUSP00000080717
Ensembl peptide - ENSMUSP00000117117
NCBI entrez gene - 12654     See in Manteia.
MGI - MGI:1340899
RefSeq - XM_006529111
RefSeq - XM_006529112
RefSeq - NM_007695
RefSeq Peptide - NP_031721
swissprot - Q61362
swissprot - D3Z2Z5
swissprot - D3YXU4
Ensembl - ENSMUSG00000064246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CHI3L1ENSG00000133048Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chit1 / Q9D7Q1 / Chitotriosidase-1 / Q13231* / chitinase 1*ENSMUSG0000002645047
Chia1 / Q91XA9 / Acidic mammalian chitinase / CHIA* / Q9BZP6* / chitinase, acidic*ENSMUSG0000006277846
Ovgp1 / Q62010 / Oviduct-specific glycoprotein / Q12889* / oviductal glycoprotein 1*ENSMUSG0000007434044
Chil3 / O35744 / Chitinase-like protein 3 / CHIA* / Q9BZP6* / chitinase, acidic*ENSMUSG0000004080942
Chil4 / Q91Z98 / Chitinase-like protein 4 / CHIA* / Q9BZP6* / chitinase, acidic*ENSMUSG0000006377942
Chil5 / chitinase-like 5 / CHIA* / Q9BZP6* / chitinase, acidic*ENSMUSG0000004387341
Chil6 / chitinase-like 6 / CHIA* / Q9BZP6* / chitinase, acidic*ENSMUSG0000002790240


Protein motifs (from Interpro)
Interpro ID Name
 IPR001223  Glycoside hydrolase family 18, catalytic domain
 IPR011583  Chitinase II
 IPR017853  Glycoside hydrolase superfamily
 IPR028538  Chitinase-3-like protein 1
 IPR029070  Chitinase insertion domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IDA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0070741 response to interleukin-6 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0072606 interleukin-8 secretion IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0008061 chitin binding ISO


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0008089 abnormal T-helper 2 cell number "anomaly in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chil1tm1Eli/Chil1tm1Eli,Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008091 decreased T-helper 2 cell number "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbtps1tm1Jdh/Mbtps1tm1Jdh,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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