ENSG00000133048


Homo sapiens

Features
Gene ID: ENSG00000133048
  
Biological name :CHI3L1
  
Synonyms : CHI3L1 / chitinase 3 like 1 / P36222
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 203178931
Gene end: 203186749
  
Corresponding Affymetrix probe sets: 209395_at (Human Genome U133 Plus 2.0 Array)   209396_s_at (Human Genome U133 Plus 2.0 Array)   216546_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000255409
Ensembl peptide - ENSP00000385350
NCBI entrez gene - 1116     See in Manteia.
OMIM - 601525
RefSeq - NM_001276
RefSeq Peptide - NP_001267
swissprot - A0A024R969
swissprot - H0Y3U8
swissprot - P36222
Ensembl - ENSG00000133048
  
Related genetic diseases (OMIM): 181500 - {Schizophrenia, susceptibility to}, 181500
  611960 - {Asthma-related traits, susceptibility to, 7}, 611960
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Chil1ENSMUSG00000064246Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHIT1 / Q13231 / chitinase 1ENSG0000013306353
CHIA / Q9BZP6 / chitinase, acidicENSG0000013421651
CHI3L2 / Q15782 / chitinase 3 like 2ENSG0000006488651
OVGP1 / Q12889 / oviductal glycoprotein 1ENSG0000008546546


Protein motifs (from Interpro)
Interpro ID Name
 IPR001223  Glycoside hydrolase family 18, catalytic domain
 IPR011583  Chitinase II
 IPR017853  Glycoside hydrolase superfamily
 IPR028538  Chitinase-3-like protein 1
 IPR029070  Chitinase insertion domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEP
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity ISS
 biological_processGO:0009612 response to mechanical stimulus IEP
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation ISS
 biological_processGO:0030324 lung development IMP
 biological_processGO:0034612 response to tumor necrosis factor IEP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0051216 cartilage development NAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070555 response to interleukin-1 IEP
 biological_processGO:0070741 response to interleukin-6 IEP
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor ISS
 biological_processGO:0072606 interleukin-8 secretion ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005201 extracellular matrix structural constituent NAS
 molecular_functionGO:0008061 chitin binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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