ENSG00000133063


Homo sapiens

Features
Gene ID: ENSG00000133063
  
Biological name :CHIT1
  
Synonyms : CHIT1 / chitinase 1 / Q13231
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q32.1
Gene start: 203212827
Gene end: 203273641
  
Corresponding Affymetrix probe sets: 208168_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356198
Ensembl peptide - ENSP00000423778
Ensembl peptide - ENSP00000421617
Ensembl peptide - ENSP00000255427
NCBI entrez gene - 1118     See in Manteia.
OMIM - 600031
RefSeq - NM_001256125
RefSeq - NM_001270509
RefSeq - NM_003465
RefSeq Peptide - NP_003456
RefSeq Peptide - NP_001243054
swissprot - Q13231
swissprot - D6REY1
Ensembl - ENSG00000133063
  
Related genetic diseases (OMIM): 614122 - [Chitotriosidase deficiency], 614122
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Chit1ENSMUSG00000026450Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHIA / Q9BZP6 / chitinase, acidicENSG0000013421653
CHI3L1 / P36222 / chitinase 3 like 1ENSG0000013304844
CHI3L2 / Q15782 / chitinase 3 like 2ENSG0000006488643
OVGP1 / Q12889 / oviductal glycoprotein 1ENSG0000008546543


Protein motifs (from Interpro)
Interpro ID Name
 IPR001223  Glycoside hydrolase family 18, catalytic domain
 IPR001579  Glycoside hydrolase, chitinase active site
 IPR002557  Chitin binding domain
 IPR011583  Chitinase II
 IPR017853  Glycoside hydrolase superfamily
 IPR029070  Chitinase insertion domain superfamily
 IPR036508  Chitin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000272 polysaccharide catabolic process IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006030 chitin metabolic process IEA
 biological_processGO:0006032 chitin catabolic process TAS
 biological_processGO:0006955 immune response NAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009617 response to bacterium TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044245 polysaccharide digestion TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004568 chitinase activity TAS
 molecular_functionGO:0008061 chitin binding IEA
 molecular_functionGO:0008843 endochitinase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA


Pathways (from Reactome)
Pathway description
Digestion of dietary carbohydrate
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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