ENSMUSG00000066043


Mus musculus

Features
Gene ID: ENSMUSG00000066043
  
Biological name :Phactr4
  
Synonyms : Phactr4 / Phosphatase and actin regulator 4 / Q501J7
  
Possible biological names infered from orthology : Q8IZ21
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.3
Gene start: 132355923
Gene end: 132422489
  
Corresponding Affymetrix probe sets: 10516910 (MoGene1.0st)   1432844_at (Mouse Genome 430 2.0 Array)   1434258_s_at (Mouse Genome 430 2.0 Array)   1454380_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119767
Ensembl peptide - ENSMUSP00000122194
Ensembl peptide - ENSMUSP00000081185
Ensembl peptide - ENSMUSP00000081270
Ensembl peptide - ENSMUSP00000099628
NCBI entrez gene - 100169     See in Manteia.
MGI - MGI:2140327
RefSeq - XM_006538457
RefSeq - XM_006538456
RefSeq - NM_001161797
RefSeq - NM_175306
RefSeq - XM_011250172
RefSeq Peptide - NP_780515
RefSeq Peptide - NP_001155269
swissprot - Q501J7
swissprot - A0A0A0MQL5
swissprot - A0A0A0MQJ4
Ensembl - ENSMUSG00000066043
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phactr4aENSDARG00000015552Danio rerio
 Q6PEI3ENSDARG00000032221Danio rerio
 PHACTR4ENSGALG00000042485Gallus gallus
 Q8IZ21ENSG00000204138Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q2M3X8 / Phactr1 / Phosphatase and actin regulator 1 / Q9C0D0*ENSMUSG0000005472834
Phactr2 / phosphatase and actin regulator 2 / O75167*ENSMUSG0000006286632
Q8BYK5 / Phactr3 / phosphatase and actin regulator 3 / Q96KR7*ENSMUSG0000002752527


Protein motifs (from Interpro)
Interpro ID Name
 IPR004018  RPEL repeat
 IPR029984  Phosphatase and actin regulator 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0007266 Rho protein signal transduction IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0043085 positive regulation of catalytic activity IDA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0048484 enteric nervous system development IMP
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0061386 closure of optic fissure IMP
 biological_processGO:2001045 negative regulation of integrin-mediated signaling pathway IMP
 cellular_componentGO:0005622 intracellular IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA
 molecular_functionGO:0008157 protein phosphatase 1 binding IDA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA
 molecular_functionGO:0072542 protein phosphatase activator activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

Allelic Composition: E2f1tm1Meg/E2f1tm1Meg,Phactr4humdy/Phactr4humdy
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: E2f1tm1Meg/E2f1+,Phactr4humdy/Phactr4humdy
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Prkcitm1Rfar/Prkci+,Tg(Ckmm-cre)5Khn/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Phactr4humdy/Phactr4humdy
Genetic Background: C.B6-Phactr4humdy

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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