ENSMUSG00000066687


Mus musculus

Features
Gene ID: ENSMUSG00000066687
  
Biological name :Zbtb16
  
Synonyms : Zbtb16 / zinc finger and BTB domain containing 16
  
Possible biological names infered from orthology : Q05516
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.3
Gene start: 48654297
Gene end: 48836222
  
Corresponding Affymetrix probe sets: 10593225 (MoGene1.0st)   1419874_x_at (Mouse Genome 430 2.0 Array)   1427638_at (Mouse Genome 430 2.0 Array)   1439163_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091374
Ensembl peptide - ENSMUSP00000150887
NCBI entrez gene - 235320     See in Manteia.
MGI - MGI:103222
RefSeq - XM_006510258
RefSeq - NM_001033324
RefSeq Peptide - NP_001028496
swissprot - Q3UQ17
Ensembl - ENSMUSG00000066687
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zbtb16aENSDARG00000007184Danio rerio
 zbtb16bENSDARG00000074526Danio rerio
 ZBTB32ENSGALG00000038540Gallus gallus
 Q05516ENSG00000109906Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zbtb39 / zinc finger and BTB domain containing 39 / O15060*ENSMUSG0000004461723
Q9JKD9 / Zbtb32 / zinc finger and BTB domain containing 32 / Q9Y2Y4*ENSMUSG0000000631019


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001823 mesonephros development IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0007417 central nervous system development IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0030097 hemopoiesis IDA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation ISS
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0035136 forelimb morphogenesis IMP
 biological_processGO:0035137 hindlimb morphogenesis IMP
 biological_processGO:0042733 embryonic digit morphogenesis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation ISO
 biological_processGO:0045638 negative regulation of myeloid cell differentiation IDA
 biological_processGO:0045778 positive regulation of ossification ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0048133 male germ-line stem cell asymmetric division IMP
 biological_processGO:0051138 positive regulation of NK T cell differentiation IMP
 biological_processGO:0051216 cartilage development ISO
 biological_processGO:0061036 positive regulation of cartilage development ISS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016604 nuclear body ISS
 cellular_componentGO:0016605 PML body ISS
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0017053 transcriptional repressor complex ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000159 abnormal xiphoid process "malformed posterior tip of the sternum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:42932]
Show

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000413 polyphalangy "increased number of phalanges in any of the digits" [J:13069, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu-Sfd/Zbtb16+
Genetic Background: involves: C57BL/6 * Swiss

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6 * Swiss

 MP:0000464 increased number of presacral vertebrae "greater number of the vertebrae anterior to the sacrum" [J:13069]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: B10.C3-Zbtb16lu

 MP:0000480 increased number of ribs "greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000482 long fibula "increased length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000556 abnormal hindlimb morphology "malformation of the entire posterior extremities" [MGI:tc]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16pnky/Zbtb16pnky
Genetic Background: CBA/CaJAnu-Zbtb16pnky/Apb

 MP:0000558 abnormal tibia morphology "atructural anomaly of the medial and larger of the two bones of the lower leg" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu-Sfd/Zbtb16+
Genetic Background: involves: C57BL/6 * Swiss

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6 * Swiss

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Zbtb16pnky/Zbtb16pnky
Genetic Background: CBA/CaJAnu-Zbtb16pnky/Apb

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6 * Swiss

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000568 ectopic digits "positional abnormality of a digit" [J:50311]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000571 interdigital webbing "fold of skin, or web, between the toes that is not normally present" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6 * Swiss

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tubb2bbrdp/Tubb2b+
Genetic Background: involves: A/J * FVB

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B6.C3-Zbtb16Lu

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: involves: C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Zbtb16pnky/Zbtb16pnky
Genetic Background: CBA/CaJAnu-Zbtb16pnky/Apb

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B6.C3-Zbtb16Lu

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6 * Swiss

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb16lu-Sfd/Zbtb16+
Genetic Background: involves: C57BL/6 * Swiss

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002187 abnormal fibula morphology "malformation of the lateral and smaller bone of the lower limb" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002543 brachyphalangia "abnormally short phalanges" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bace1tm1Bux/Bace1tm1Bux
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002685 abnormal proliferation of spermatogonia "reduction in the proliferation of the spermatogonial stem cells either due to reduced mitosis or increased apoptosis" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62271]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6 * Swiss

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0003857 abnormal hindlimb zeugopod morphology 
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Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004049 acute promyelocytic leukemia "rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gtf2h5tm1.1Wive/Gtf2h5tm1.1Wive
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

 MP:0004372 bowed fibula "increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

 MP:0004616 lumbar vertebral transformation "homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004617 sacral vertebral transformation "homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004618 thoracic vertebral transformation "homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004642 fused metatarsal bones "improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004651 increased thoracic vertebrae number "increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004679 xiphoid process foramen "the appearance of a hole or holes in the posterior tip of the sternum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004694 absent patella "absence of the large sesamoid bone that covers the anterior surface of the knee" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B6.C3-Zbtb16Lu

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

 MP:0005109 abnormal talus morphology "malformation of the bone that articlulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B6.C3-Zbtb16Lu

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: Not Specified

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005430 absent fibula "missing the lateral and shorter of the two bones of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86196]
Show

Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Fbn1Tsk/Fbn1+,Tg(Tcra2C,Tcrb2C)1Dlo/?
Genetic Background: involves: C57BL/10 * DBA/2

 MP:0008159 increased diameter of fibula "increased width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16lu-Sfd/Zbtb16lu-Sfd
Genetic Background: involves: C57BL/6 * Swiss

Allelic Composition: Zbtb167t/Zbtb167t
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad3tm1Xfw/Smad3tm1Xfw
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Zbtb16tm1Geno/Zbtb16tm1Geno
Genetic Background: Not Specified

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
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Allelic Composition: Zbtb16tm1Geno/Zbtb16tm1Geno
Genetic Background: Not Specified

Allelic Composition: Zbtb16tm2Geno/Zbtb16tm2Geno
Genetic Background: Not Specified

 MP:0008985 hemimelia "congenital absence of part of an extremity, such as absent fibula with the tibia present" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cd3etm1Cpt/Cd3etm1Cpt,Tg(CD3E)26Cpt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Zbtb16tm1Geno/Zbtb16tm1Geno
Genetic Background: Not Specified

Allelic Composition: Zbtb16tm2Geno/Zbtb16tm2Geno
Genetic Background: Not Specified

 MP:0012167 abnormal epigenetic regulation of gene expression "any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence" [GO:0040029]
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Allelic Composition: Zbtb16tm1Geno/Zbtb16tm1Geno
Genetic Background: Not Specified

 MP:0012284 increased sternebra number "increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:anna]
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Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16lu
Genetic Background: B10.C3-Zbtb16lu

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: C3H/He

Allelic Composition: Zbtb16lu/Zbtb16+
Genetic Background: B10.C3-Zbtb16lu

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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