ENSMUSG00000068037


Mus musculus

Features
Gene ID: ENSMUSG00000068037
  
Biological name :Mas1
  
Synonyms : Mas1 / P30554 / Proto-onco Mas
  
Possible biological names infered from orthology : MAS1 proto-oncogene, G protein-coupled receptor / P04201
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A1
Gene start: 12841079
Gene end: 12868143
  
Corresponding Affymetrix probe sets: 10447848 (MoGene1.0st)   1422936_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124952
Ensembl peptide - ENSMUSP00000124901
Ensembl peptide - ENSMUSP00000125108
Ensembl peptide - ENSMUSP00000132300
Ensembl peptide - ENSMUSP00000131341
Ensembl peptide - ENSMUSP00000086409
Ensembl peptide - ENSMUSP00000123902
Ensembl peptide - ENSMUSP00000124295
Ensembl peptide - ENSMUSP00000124879
NCBI entrez gene - 17171     See in Manteia.
MGI - MGI:96918
RefSeq - XM_017317274
RefSeq - XM_011246191
RefSeq - XM_011246192
RefSeq - XM_011246193
RefSeq - XM_017317270
RefSeq - XM_017317271
RefSeq - XM_017317272
RefSeq - XM_017317273
RefSeq - NM_008552
RefSeq - XM_006523293
RefSeq - XM_006523294
RefSeq - XM_006523296
RefSeq - XM_006523297
RefSeq - XM_006523299
RefSeq - XM_011246190
RefSeq Peptide - NP_032578
swissprot - E0CX70
swissprot - E0CX57
swissprot - E0CYD1
swissprot - P30554
swissprot - Q0VB49
swissprot - E0CX40
Ensembl - ENSMUSG00000068037
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000011622Gallus gallus
 MAS1ENSG00000130368Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mrgprh / Q99MT8 / Mas-related G-protein coupled receptor member H ENSMUSG0000005940842
Mrgpra9 / Q96LB2* / Q96LA9* / Q96LB0* / Q96LB1* / MRGPRX1* / MRGPRX2* / MRGPRX3* / MRGPRX4* / MAS related GPR family member X1* / MAS related GPR family member X3* / MAS related GPR family ...ENSMUSG0000007411132
Q3UG61 / Mrgprb1 / Mas-related G-protein coupled receptor member B1 ENSMUSG0000007054732
Mrgprd / Q91ZB8 / Mas-related G-protein coupled receptor member D / Q8TDS7* / MAS related GPR family member D*ENSMUSG0000005120732
Q3KNA1 / Mrgprb2 / Mas-related G-protein coupled receptor member B2 ENSMUSG0000005042532
Q3UG50 / Mrgprx2 / Mas-related G-protein coupled receptor member X2 ENSMUSG0000007410932
Q8CIP3 / Mrgprx1 / Mas-related G-protein coupled receptor member X1 ENSMUSG0000007055230
Mrgpra1 / Q96LB2* / Q96LA9* / Q96LB0* / Q96LB1* / MRGPRX1* / MRGPRX2* / MRGPRX3* / MRGPRX4* / MAS related GPR family member X1* / MAS related GPR family member X3* / MAS related GPR family ...ENSMUSG0000005065030
Q91ZC0 / Mrgprb4 / Mas-related G-protein coupled receptor member B4 ENSMUSG0000007055030
Q91WW2 / Mrgpra4 / Mas-related G-protein coupled receptor member A4 / Q96LB2* / Q96LA9* / Q96LB0* / Q96LB1* / MRGPRX2* / MRGPRX3* / MRGPRX4* / MRGPRX1* / MAS related GPR family member X1* ...ENSMUSG0000006717329
Q91ZB9 / Mrgprb5 / Mas-related G-protein coupled receptor member B5 ENSMUSG0000007055128
Q91ZC6 / Mrgpra6 / Mus musculus MAS-related GPR, member A6 (Mrgpra6), transcript variant 1, mRNA. / Q96LB2* / Q96LA9* / Q96LB0* / Q96LB1* / MRGPRX3* / MRGPRX4* / MRGPRX1* / MRGPRX2* / MAS r...ENSMUSG0000005230328
Mrgpra3 / Q96LB2* / Q96LA9* / Q96LB0* / Q96LB1* / MRGPRX1* / MRGPRX2* / MRGPRX3* / MRGPRX4* / MAS related GPR family member X1* / MAS related GPR family member X3* / MAS related GPR family ...ENSMUSG0000007869828
Q7TN51 / Mrgprb8 / Mas-related G-protein coupled receptor member B8 ENSMUSG0000005087028
Mrgpra2b / Q96LB2* / Q96LA9* / Q96LB0* / Q96LB1* / MRGPRX1* / MRGPRX2* / MRGPRX3* / MRGPRX4* / MAS related GPR family member X1* / MAS related GPR family member X3* / MAS related GPR family...ENSMUSG0000009671927
Q91ZC1 / Mrgprb3 / Mas-related G-protein coupled receptor member B3 ENSMUSG0000007054627
Mrgpra2a / Q96LB2* / Q96LA9* / Q96LB0* / Q96LB1* / MRGPRX1* / MRGPRX2* / MRGPRX3* / MRGPRX4* / MAS related GPR family member X1* / MAS related GPR family member X3* / MAS related GPR family...ENSMUSG0000009397327
Mrgprf / Q8VCJ6 / Mas-related G-protein coupled receptor member F / Q96AM1* / MAS related GPR family member F*ENSMUSG0000003107027
Mrgpre / Q91ZB7 / Mas-related G-protein coupled receptor member E / Q86SM8* / MAS related GPR family member E*ENSMUSG0000004896524
Mrgprg / Q91ZB5 / Mas-related G-protein coupled receptor member G / Q86SM5* / MAS related GPR family member G*ENSMUSG0000005027619


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000820  Proto-oncogene Mas
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR026234  Mas-related G protein-coupled receptor family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IMP
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0021766 hippocampus development IEA
 biological_processGO:0034698 response to gonadotropin IEA
 biological_processGO:0038166 angiotensin-activated signaling pathway IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0060732 positive regulation of inositol phosphate biosynthetic process IEA
 biological_processGO:0070528 protein kinase C signaling ISO
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001595 angiotensin receptor activity IMP
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0042277 peptide binding IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002828 abnormal glomerular capsule "anomalous structure or development of the expanded beginning of a nephron that contains the glomerulus" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002959 increased microalbumin excretion "greater than the normal amount of fragments of this protein voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: EgfrMhdadsk5/Egfr+
Genetic Background: C3HeB/FeJ-EgfrMhdadsk5/Ieg

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005526 decreased renal plasma flow rate "less than the normal volume of plasma passing throught the kidney per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005527 increased glomerular filtration rate "greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005531 increased renal vascular resistance "greater than the normal force opposing blood flow in the kidney blood vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005557 increased creatinine clearance "greater than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011432 decreased urine flow rate "reduced volume of urine produced in a specified period of time" [MGI:anna]
Show

Allelic Composition: Tmem100tm1.1Ysai/Tmem100tm2.1Ysai,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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