ENSMUSG00000068329


Mus musculus

Features
Gene ID: ENSMUSG00000068329
  
Biological name :Htra2
  
Synonyms : Htra2 / Q9JIY5 / Serine protease HTRA2, mitochondrial
  
Possible biological names infered from orthology : HtrA serine peptidase 2 / O43464
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 83051266
Gene end: 83055273
  
Corresponding Affymetrix probe sets: 10545629 (MoGene1.0st)   1436269_s_at (Mouse Genome 430 2.0 Array)   1460495_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118234
Ensembl peptide - ENSMUSP00000138153
Ensembl peptide - ENSMUSP00000138148
Ensembl peptide - ENSMUSP00000087073
Ensembl peptide - ENSMUSP00000109595
Ensembl peptide - ENSMUSP00000109596
Ensembl peptide - ENSMUSP00000115547
NCBI entrez gene - 64704     See in Manteia.
MGI - MGI:1928676
RefSeq - NM_019752
RefSeq Peptide - NP_062726
swissprot - F6XUR8
swissprot - Q9JIY5
swissprot - S4R1A8
swissprot - D3YX28
swissprot - S4R1B3
swissprot - D3YX27
swissprot - F6TCV0
Ensembl - ENSMUSG00000068329
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX510654.1ENSDARG00000116494Danio rerio
 CR848040.4ENSDARG00000115106Danio rerio
 CT027677.1ENSDARG00000114913Danio rerio
 si:dkey-112g5.11ENSDARG00000092094Danio rerio
 si:dkey-112g5.12ENSDARG00000115120Danio rerio
 si:dkey-112g5.12ENSDARG00000076713Danio rerio
 si:dkey-112g5.12ENSDARG00000069909Danio rerio
 si:dkey-112g5.13ENSDARG00000092061Danio rerio
 si:dkey-112g5.15ENSDARG00000094236Danio rerio
 si:dkey-112g5.16ENSDARG00000092202Danio rerio
 si:dkey-19p15.4ENSDARG00000111633Danio rerio
 si:dkey-19p15.4ENSDARG00000095314Danio rerio
 si:dkey-33c12.10ENSDARG00000094403Danio rerio
 si:dkey-33c12.11ENSDARG00000093005Danio rerio
 si:dkey-33c12.12ENSDARG00000095545Danio rerio
 si:dkey-33c12.14ENSDARG00000092380Danio rerio
 si:dkey-84o3.2ENSDARG00000094749Danio rerio
 si:dkey-84o3.3ENSDARG00000070138Danio rerio
 si:dkey-84o3.3ENSDARG00000095687Danio rerio
 si:dkey-84o3.4ENSDARG00000094995Danio rerio
 si:dkey-84o3.6ENSDARG00000094878Danio rerio
 si:dkey-84o3.7ENSDARG00000092133Danio rerio
 zgc:173425ENSDARG00000094741Danio rerio
 zgc:174193ENSDARG00000092625Danio rerio
 zgc:174193ENSDARG00000088743Danio rerio
 HTRA2ENSG00000115317Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htra4 / A2RT60 / Serine protease HTRA4 / P83105* / HtrA serine peptidase 4*ENSMUSG0000003740641
Htra3 / Q9D236 / Serine protease HTRA3 / P83110* / HtrA serine peptidase 3*ENSMUSG0000002909640
Htra1 / Q9R118 / Serine protease HTRA1 / Q92743* / HtrA serine peptidase 1*ENSMUSG0000000620540


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR001940  Peptidase S1C
 IPR009003  Peptidase S1, PA clan
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0009635 response to herbicide IEA
 biological_processGO:0010822 positive regulation of mitochondrion organization IEA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0019742 pentacyclic triterpenoid metabolic process IEA
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0044257 cellular protein catabolic process IEA
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 biological_processGO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization IMP
 biological_processGO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0035631 CD40 receptor complex IDA
 cellular_componentGO:1905370 serine-type endopeptidase complex IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IMP
 molecular_functionGO:0008236 serine-type peptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pou4f1tm1Rsd/Pou4f1tm1Rsd
Genetic Background: Not Specified

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0001388 abnormal stationary movement "altered ability or inability to change body posture or shift a body part" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stat3tm1Flv/Stat3tm1Flv,Tg(Tek-cre)1Xyfu/0
Genetic Background: involves: C57BL/6

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Fasltm1.1Lest/Fasltm1.1Lest
Genetic Background: B6.129-Fasltm1.1Lest

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0002690 akinesia "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0003242 loss of basal ganglia neurons "loss of neurons in the basal ganglia of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0003643 spleen atrophy "wasting of the spleen resulting in reduced size" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0005323 dystonia "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo,Diablotm1Mak/Diablotm1Mak
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Axin1Fu/Axin1+
Genetic Background: 129P4.Cg-Axin1Fu/J

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htra2tm1Jdo/Htra2tm1Jdo
Genetic Background: involves: 129P/Ola * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: involves: C3H/HeJ * C57BL/6J * CAST/Ei

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

 MP:0011632 dilated mitochondria "the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011634 abnormal mitochondrial inner membrane morphology "any structural anomaly of the inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope, which is highly folded to form cristae" [GO:0005743]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Htra2tm1.2Hohj/Htra2tm1.2Hohj
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Htra2tm1.1Hohj/Htra2tm1.1Hohj,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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