ENSMUSG00000006205


Mus musculus

Features
Gene ID: ENSMUSG00000006205
  
Biological name :Htra1
  
Synonyms : Htra1 / Q9R118 / Serine protease HTRA1
  
Possible biological names infered from orthology : HtrA serine peptidase 1 / Q92743
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 130936111
Gene end: 130985660
  
Corresponding Affymetrix probe sets: 10558150 (MoGene1.0st)   1416749_at (Mouse Genome 430 2.0 Array)   1438251_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006367
NCBI entrez gene - 56213     See in Manteia.
MGI - MGI:1929076
RefSeq - NM_019564
RefSeq Peptide - NP_062510
swissprot - Q9R118
Ensembl - ENSMUSG00000006205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A9JRB3ENSDARG00000014907Danio rerio
 htra1aENSDARG00000032831Danio rerio
 HTRA1ENSGALG00000041140Gallus gallus
 HTRA1ENSG00000166033Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Htra4 / A2RT60 / Serine protease HTRA4 / P83105* / HtrA serine peptidase 4*ENSMUSG0000003740655
Htra3 / Q9D236 / Serine protease HTRA3 / P83110* / HtrA serine peptidase 3*ENSMUSG0000002909653
Htra2 / Q9JIY5 / Serine protease HTRA2, mitochondrial / O43464* / HtrA serine peptidase 2*ENSMUSG0000006832938


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR001478  PDZ domain
 IPR001940  Peptidase S1C
 IPR002350  Kazal domain
 IPR009003  Peptidase S1, PA clan
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR036034  PDZ superfamily
 IPR036058  Kazal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001890 placenta development IMP
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0050687 negative regulation of defense response to virus IEA
 biological_processGO:0060718 chorionic trophoblast cell differentiation IMP
 biological_processGO:0097187 dentinogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003279 aneurysm "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ryr2tm1.1Swch/Ryr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ryr2tm1.1Swch/Ryr2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkaptm1c(KOMP)Wtsi/Ikbkaptm1c(KOMP)Wtsi,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkaptm1c(KOMP)Wtsi/Ikbkaptm1c(KOMP)Wtsi,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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