ENSMUSG00000068587


Mus musculus

Features
Gene ID: ENSMUSG00000068587
  
Biological name :Mgam
  
Synonyms : maltase-glucoamylase / Mgam
  
Possible biological names infered from orthology : O43451
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B1
Gene start: 40628831
Gene end: 40769123
  
Corresponding Affymetrix probe sets: 10537509 (MoGene1.0st)   1456777_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143946
Ensembl peptide - ENSMUSP00000144680
Ensembl peptide - ENSMUSP00000144652
Ensembl peptide - ENSMUSP00000144627
Ensembl peptide - ENSMUSP00000071466
NCBI entrez gene - 232714     See in Manteia.
MGI - MGI:1203495
RefSeq - XM_011241330
RefSeq - NM_001171003
RefSeq - XM_006506048
RefSeq Peptide - NP_001164474
swissprot - B5THE2
swissprot - Q6XK23
swissprot - A0A0J9YVE6
swissprot - A0A0J9YVJ0
Ensembl - ENSMUSG00000068587
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01079192.1ENSDARG00000101629Danio rerio
 CABZ01088484.1ENSDARG00000104569Danio rerio
 MGAMENSG00000257335Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sis / sucrase-isomaltase / SI* / P14410*ENSMUSG0000002779059
Gaa / P70699 / Lysosomal alpha-glucosidase / P10253* / glucosidase alpha, acid*ENSMUSG0000002557921
Ganab / Q8BHN3 / Neutral alpha-glucosidase AB / Q14697* / glucosidase II alpha subunit*ENSMUSG0000007165013
Ganc / glucosidase alpha, neutral C / Q8TET4*ENSMUSG0000006264612
Q69ZQ1 / AI464131 / Myosis-regulating glycosidase / MYORG* / Q6NSJ0* / myogenesis regulating glycosidase (putative)*ENSMUSG000000463127


Protein motifs (from Interpro)
Interpro ID Name
 IPR000322  Glycoside hydrolase family 31
 IPR000519  P-type trefoil domain
 IPR011013  Galactose mutarotase-like domain superfamily
 IPR017853  Glycoside hydrolase superfamily
 IPR030458  Glycosyl hydrolases family 31, active site
 IPR030459  Glycosyl hydrolases family 31, conserved site
 IPR031727  Galactose mutarotase, N-terminal barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000023 maltose metabolic process IEA
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004339 glucan 1,4-alpha-glucosidase activity IEA
 molecular_functionGO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA
 molecular_functionGO:0004558 alpha-1,4-glucosidase activity IEA
 molecular_functionGO:0016160 amylase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016798 hydrolase activity, acting on glycosyl bonds IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0032450 maltose alpha-glucosidase activity IEA
 molecular_functionGO:0090599 alpha-glucosidase activity IEA


Pathways (from Reactome)
Pathway description
Digestion of dietary carbohydrate
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002715 reduced glycogen catabolism rate "decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rtn4rtm1Gogo/Rtn4r+
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000068587 Mgam / maltase-glucoamylase / O43451*  / complex






 

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