ENSMUSG00000068745


Mus musculus

Features
Gene ID: ENSMUSG00000068745
  
Biological name :Mybphl
  
Synonyms : Mybphl / Myosin-binding protein H-like / Q5FW53
  
Possible biological names infered from orthology : A2RUH7
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F3
Gene start: 108364911
Gene end: 108380057
  
Corresponding Affymetrix probe sets: 10495306 (MoGene1.0st)   1430269_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000088051
NCBI entrez gene - 68753     See in Manteia.
MGI - MGI:1916003
RefSeq - NM_026831
RefSeq Peptide - NP_081107
swissprot - Q5FW53
Ensembl - ENSMUSG00000068745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mybphaENSDARG00000058799Danio rerio
 mybphbENSDARG00000003081Danio rerio
 MYBPHENSGALG00000000164Gallus gallus
 A2RUH7ENSG00000221986Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mybph / P70402 / Mus musculus myosin binding protein H (Mybph), transcript variant 2, mRNA. / Q13203* / myosin binding protein H*ENSMUSG0000004245165
Mybpc1 / myosin binding protein C, slow type / Q00872*ENSMUSG0000002006148
Mybpc3 / myosin binding protein C, cardiac / Q14896*ENSMUSG0000000210047
Mybpc2 / Q5XKE0 / Myosin-binding protein C, fast-type / Q14324*ENSMUSG0000003867047
Igfn1 / Q3KNY0 / Immunoglobulin-like and fibronectin type III domain-containing protein 1 / Q86VF2* / immunoglobulin-like and fibronectin type III domain containing 1*ENSMUSG0000005198525
Myom1 / Q62234 / Myomesin-1 / P52179*ENSMUSG0000002404920
Myom2 / myomesin 2 / P54296*ENSMUSG0000003146120
Myom3 / A2ABU4 / Myomesin-3 / Q5VTT5*ENSMUSG0000003713919


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006941 striated muscle contraction IBA
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0045214 sarcomere organization IBA
 biological_processGO:0071688 striated muscle myosin thick filament assembly IBA
 cellular_componentGO:0005859 muscle myosin complex IBA
 cellular_componentGO:0030018 Z disc IBA
 cellular_componentGO:0031430 M band IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008307 structural constituent of muscle IBA
 molecular_functionGO:0051015 actin filament binding IBA
 molecular_functionGO:0051371 muscle alpha-actinin binding IBA
 molecular_functionGO:0097493 structural molecule activity conferring elasticity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0003686 abnormal eye muscle morphology "malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0003722 absent ureter "missing the tube that conducts the urine from the renal pelvis to the bladder" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0004268 abnormal optic stalk morphology "any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0004269 abnormal optic cup morphology "any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0006063 abnormal inferior vena cava morphology "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0009495 abnormal common bile duct morphology "any structural anomaly of the part of the biliary tree formed by the union of the cystic duct and the common hepatic duct" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0009770 abnormal optic chiasm morphology "an anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0011683 dual inferior vena cava "presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein" [MGI:csmith, PMID:10835118]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0013186 abnormal basilar artery morphology "any structural anomaly of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [MGI:anna]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0013840 absent segment of posterior cerebral artery "absence of a portion of one of a pair of blood vessels that supplies oxygenated blood to the posterior aspect of the brain" [UBERON:0001636]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0013848 subcutaneous edema "accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0013877 abnormal ductus venosus valve morphology "any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0013967 abnormal infrahyoid muscle connection 
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0013971 blood in lymph vessels 
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0014001 abnormal vertebral artery topology "abnormal position of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck" [MGI:csmith]
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Allelic Composition: Msx1tm1b(KOMP)Wtsi/Msx1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Msx1tm1b(KOMP)Wtsi/J

Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

 MP:0014017 abnormal Wolffian duct connection "aberrant attachment or incomplete connection of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) to the cloaca " [ISBN:0-683-40008-8]
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Allelic Composition: Mybphltm1b(KOMP)Wtsi/Mybphltm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mybphltm1b(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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