ENSMUSG00000068917


Mus musculus

Features
Gene ID: ENSMUSG00000068917
  
Biological name :Clk2
  
Synonyms : Clk2 / Dual specificity protein kinase CLK2 / O35491
  
Possible biological names infered from orthology : CDC like kinase 2 / P49760
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 89164795
Gene end: 89176921
  
Corresponding Affymetrix probe sets: 10493394 (MoGene1.0st)   1417743_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113390
Ensembl peptide - ENSMUSP00000122634
Ensembl peptide - ENSMUSP00000122202
Ensembl peptide - ENSMUSP00000115761
Ensembl peptide - ENSMUSP00000113861
Ensembl peptide - ENSMUSP00000088445
NCBI entrez gene - 12748     See in Manteia.
MGI - MGI:1098669
RefSeq - NM_001163432
RefSeq - NM_007712
RefSeq Peptide - NP_001156904
RefSeq Peptide - NP_031738
swissprot - E9Q5Y1
swissprot - O35491
swissprot - D6RG48
swissprot - D3Z7L4
swissprot - D3Z4P7
swissprot - F8WHX0
Ensembl - ENSMUSG00000068917
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 clk2aENSDARG00000062954Danio rerio
 clk2bENSDARG00000059870Danio rerio
 CLK2ENSGALG00000029444Gallus gallus
 CLK2ENSG00000176444Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clk3 / O35492 / Dual specificity protein kinase CLK3 / P49761* / CDC like kinase 3*ENSMUSG0000003231660
Clk4 / O35493 / Dual specificity protein kinase CLK4 / Q9HAZ1* / CDC like kinase 4*ENSMUSG0000002038555
Clk1 / P22518 / Dual specificity protein kinase CLK1 / P49759* / CDC like kinase 1*ENSMUSG0000002603453
Prpf4b / Q61136 / Serine/threonine-protein kinase PRP4 homolog / Q13523* / pre-mRNA processing factor 4B*ENSMUSG0000002141331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010033 response to organic substance IDA
 biological_processGO:0010212 response to ionizing radiation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0032526 response to retinoic acid IDA
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0045721 negative regulation of gluconeogenesis IMP
 biological_processGO:0046777 protein autophosphorylation IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0016607 nuclear speck IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Clk2tm1.1Ppgr/Clk2tm1.1Ppgr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6NTac * FVB/N

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clk2tm1.1Ppgr/Clk2tm1.1Ppgr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6NTac * FVB/N

 MP:0010953 abnormal fatty acid oxidation "anomaly in the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [GO:0019395]
Show

Allelic Composition: Clk2tm1.1Ppgr/Clk2tm1.1Ppgr,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6NTac * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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