Manteia

ENSMUSG00000070304

Mus musculus

Features

Gene ID:	ENSMUSG00000070304

Biological name :	Scn2b

Synonyms :	Q56A07 / Scn2b / Sodium channel subunit beta-2

Possible biological names infered from orthology :	O60939 / sodium voltage-gated channel beta subunit 2

Species:	Mus musculus

Chr. number:	9
Strand:	1
Band:	A5.2
Gene start:	45117782
Gene end:	45130070

Corresponding Affymetrix probe sets:	10584855 (MoGene1.0st) 1430648_at (Mouse Genome 430 2.0 Array) 1436134_at (Mouse Genome 430 2.0 Array) 1457144_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000091377 Ensembl peptide - ENSMUSP00000126826 NCBI entrez gene - 72821 See in Manteia. MGI - MGI:106921 RefSeq - XM_006510629 RefSeq - NM_001014761 RefSeq Peptide - NP_001014761 swissprot - Q1MXF8 swissprot - Q56A07 Ensembl - ENSMUSG00000070304

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Scn4b / Q7M729 / Sodium channel subunit beta-4 / Q8IWT1* / sodium voltage-gated channel beta subunit 4*	ENSMUSG00000046480	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR000920	Myelin P0 protein-related
IPR003599	Immunoglobulin subtype
IPR007110	Immunoglobulin-like domain
IPR013106	Immunoglobulin V-set domain
IPR013783	Immunoglobulin-like fold
IPR021157	Cytochrome c1, transmembrane anchor, C-terminal
IPR029873	Sodium channel subunit beta-2
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006814	sodium ion transport	IEA
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0034765	regulation of ion transmembrane transport	IEA
biological_process	GO:0035725	sodium ion transmembrane transport	ISO
biological_process	GO:0046684	response to pyrethroid	IEA
biological_process	GO:0060048	cardiac muscle contraction	ISO
biological_process	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	ISO
biological_process	GO:0086002	cardiac muscle cell action potential involved in contraction	ISO
biological_process	GO:0086012	membrane depolarization during cardiac muscle cell action potential	ISO
biological_process	GO:0086091	regulation of heart rate by cardiac conduction	ISO
biological_process	GO:2000649	regulation of sodium ion transmembrane transporter activity	ISO
cellular_component	GO:0001518	voltage-gated sodium channel complex	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005244	voltage-gated ion channel activity	IEA
molecular_function	GO:0005248	voltage-gated sodium channel activity	IEA
molecular_function	GO:0005272	sodium channel activity	IEA
molecular_function	GO:0017080	sodium channel regulator activity	ISO
molecular_function	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential	ISO

Pathways (from Reactome)

Pathway description

Phase 0 - rapid depolarisation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002272	abnormal nervous system electrophysiology	"anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pax3^Sp-d/Pax3⁺ Genetic Background: C57BL/6J-Pax3^Sp-d
MP:0002906	susceptibility to pharmacologically induced seizures	"inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]	Show Allelic Composition: Pax3^Sp-d/Pax3⁺ Genetic Background: C57BL/6J-Pax3^Sp-d
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Bhlha15^{tm3(cre/ERT2)Skz}/Bhlha15^{tm3(cre/ERT2)Skz} Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr