ENSMUSG00000070509


Mus musculus

Features
Gene ID: ENSMUSG00000070509
  
Biological name :Rgma
  
Synonyms : Q6PCX7 / Repulsive guidance molecule A / Rgma
  
Possible biological names infered from orthology : Q96B86 / repulsive guidance molecule BMP co-receptor a
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: D1
Gene start: 73375509
Gene end: 73419899
  
Corresponding Affymetrix probe sets: 10554150 (MoGene1.0st)   1438241_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145758
Ensembl peptide - ENSMUSP00000091870
Ensembl peptide - ENSMUSP00000112599
Ensembl peptide - ENSMUSP00000116552
NCBI entrez gene - 244058     See in Manteia.
MGI - MGI:2679262
RefSeq - NM_177740
RefSeq - XM_006540902
RefSeq Peptide - NP_808408
swissprot - D3Z4W0
swissprot - Q6PCX7
swissprot - Q8C4C4
Ensembl - ENSMUSG00000070509
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgmaENSDARG00000012248Danio rerio
 RGMAENSGALG00000039173Gallus gallus
 RGMAENSG00000182175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgmb / Q7TQ33 / RGM domain family member B / Q6NW40* / repulsive guidance molecule BMP co-receptor b*ENSMUSG0000004802745
Hfe2 / Q7TQ32 / Hemojuvelin / Q6ZVN8* / hemochromatosis type 2 (juvenile)*ENSMUSG0000003840342


Protein motifs (from Interpro)
Interpro ID Name
 IPR009496  Repulsive guidance molecule, C-terminal
 IPR010536  Repulsive guidance molecule, N-terminal
 IPR016123  Mog1/PsbP, alpha/beta/alpha sandwich
 IPR033607  Repulsive guidance molecule A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0010975 regulation of neuron projection development IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0010977 negative regulation of neuron projection development IMP
 biological_processGO:0030509 BMP signaling pathway IGI
 biological_processGO:0030510 regulation of BMP signaling pathway ISO
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0043547 positive regulation of GTPase activity IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048671 negative regulation of collateral sprouting IEA
 biological_processGO:0048681 negative regulation of axon regeneration IEA
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:1900121 negative regulation of receptor binding IMP
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity IGI
 molecular_functionGO:1990459 transferrin receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Foxa2tm1Jrt/Foxa2tm1Khk,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr