ENSMUSG00000071649


Mus musculus

Features
Gene ID: ENSMUSG00000071649
  
Biological name :B3gat3
  
Synonyms : B3gat3 / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 / P58158
  
Possible biological names infered from orthology : beta-1,3-glucuronyltransferase 3 / O94766
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 8920374
Gene end: 8927234
  
Corresponding Affymetrix probe sets: 10461305 (MoGene1.0st)   1416960_at (Mouse Genome 430 2.0 Array)   1431219_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093962
NCBI entrez gene - 72727     See in Manteia.
MGI - MGI:1919977
RefSeq - NM_024256
RefSeq Peptide - NP_077218
swissprot - P58158
Ensembl - ENSMUSG00000071649
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 b3gat3ENSDARG00000001939Danio rerio
 B3GAT3ENSG00000149541Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B3gat1 / Q9CW73 / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 / Q9P2W7* / beta-1,3-glucuronyltransferase 1*ENSMUSG0000004599443
B3gat2 / P59270 / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 / Q9NPZ5* / beta-1,3-glucuronyltransferase 2*ENSMUSG0000002615640


Protein motifs (from Interpro)
Interpro ID Name
 IPR005027  Glycosyl transferase, family 43
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IBA
 biological_processGO:0006024 glycosaminoglycan biosynthetic process IEA
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0030204 chondroitin sulfate metabolic process IBA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0050650 chondroitin sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0050651 dermatan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0090316 positive regulation of intracellular protein transport IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity IBA
 molecular_functionGO:0015020 glucuronosyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0072542 protein phosphatase activator activity IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0006204 embryonic lethality before implantation "death anytime after fertilization but before implantation (E0 to less than E4.5)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6

 MP:0011475 abnormal glycosaminoglycan level "any change in the amount of glycosaminoglycan, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit" [MGI:csmith]
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Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6

 MP:0013289 abnormal mitotic cytokinesis "any anomaly in the process that results in the division of the cytoplasm of a cell after mitosis, this process consists of two distinct processes furrowing and abscission" [GO:0000281, MGI:smb]
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Allelic Composition: Col1a1tm2(tetO-IDH2*R140Q)Ppp/Col1a1tm2(tetO-IDH2*R140Q)Ppp,Flt3tm1.1Dosm/Flt3tm1.1Dosm,Gt(ROSA)26Sortm1(rtTA*M2)Jae/?
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000071649 B3gat3 / P58158 / Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 / O94766* / beta-1,3-glucuronyltransferase 3*  / complex






 

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