ENSMUSG00000072647


Mus musculus

Features
Gene ID: ENSMUSG00000072647
  
Biological name :Adam1a
  
Synonyms : Adam1a / Disintegrin and metalloproteinase domain-containing protein 1a / O54992 / Q60813
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 121518576
Gene end: 121545482
  
Corresponding Affymetrix probe sets: 10533323 (MoGene1.0st)   10533327 (MoGene1.0st)   1417016_at (Mouse Genome 430 2.0 Array)   1427790_at (Mouse Genome 430 2.0 Array)   1427791_a_at (Mouse Genome 430 2.0 Array)   1443378_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098320
Ensembl peptide - ENSMUSP00000143668
NCBI entrez gene - 280668     See in Manteia.
MGI - MGI:2429504
RefSeq - NM_172126
RefSeq Peptide - NP_742124
swissprot - O54992
swissprot - Q3UV25
swissprot - Q3V0H1
swissprot - Q60813
Ensembl - ENSMUSG00000072647
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174164ENSDARG00000057138Danio rerio
 ENSGALG00000045145Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam1b / Q8R534 / Disintegrin and metalloproteinase domain-containing protein 1b ENSMUSG0000006243868
Adam9 / Q61072 / Disintegrin and metalloproteinase domain-containing protein 9 / Q13443* / ADAM metallopeptidase domain 9*ENSMUSG0000003155534
Adam21 / Q9JI76 / Disintegrin and metalloproteinase domain-containing protein 21 / Q9UKJ8* / ADAM metallopeptidase domain 21*ENSMUSG0000000843831
Gm5346ENSMUSG0000005019030
Adam20 / a disintegrin and metallopeptidase domain 20ENSMUSG0000004628230
Adam26b / a disintegrin and metallopeptidase domain 26BENSMUSG0000006390030
Q9R158 / Adam26a / Disintegrin and metalloproteinase domain-containing protein 26A ENSMUSG0000004851630
Adam34 / a disintegrin and metallopeptidase domain 34ENSMUSG0000007905830
Adam24 / Q9R160 / Disintegrin and metalloproteinase domain-containing protein 24 ENSMUSG0000004672329
Adam29 / ADAM metallopeptidase domain 29 / Q9UKF5*ENSMUSG0000004625829
Adam39 / a disintegrin and metallopeptidase domain 39ENSMUSG0000005403329
Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*ENSMUSG0000004346829
Adam25ENSMUSG0000007193729
Adam2 / Q60718 / Disintegrin and metalloproteinase domain-containing protein 2 / Q99965* / ADAM metallopeptidase domain 2*ENSMUSG0000002203927
Adam4 / a disintegrin and metallopeptidase domain 4ENSMUSG0000007297226
Adam32 / Q8K410 / Disintegrin and metalloproteinase domain-containing protein 32 / Q8TC27* / ADAM metallopeptidase domain 32*ENSMUSG0000003743726
Gm4787ENSMUSG0000007297425
Adam3 / F8VQ03 / A disintegrin and metallopeptidase domain 3 ENSMUSG0000003155325
Adam6a / a disintegrin and metallopeptidase domain 6AENSMUSG0000004394525
Adam6b / a disintegrin and metallopeptidase domain 6BENSMUSG0000005180424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR027442  MAP kinase activated protein kinase, C-terminal
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IBA
 biological_processGO:0006417 regulation of translation ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006508 proteolysis NAS
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0007339 binding of sperm to zona pellucida IMP
 biological_processGO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization NAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032007 negative regulation of TOR signaling IDA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase ISO
 biological_processGO:0046777 protein autophosphorylation IBA
 biological_processGO:0051973 positive regulation of telomerase activity ISO
 biological_processGO:0060999 positive regulation of dendritic spine development IMP
 biological_processGO:0090400 stress-induced premature senescence IMP
 biological_processGO:1904355 positive regulation of telomere capping ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0032156 septin cytoskeleton IDA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity NAS
 molecular_functionGO:0009931 calcium-dependent protein serine/threonine kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051019 mitogen-activated protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
MAPK6/MAPK4 signaling
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Mknk2tm1Fuku/Mknk2tm1Fuku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mknk2tm1Fuku/Mknk2tm1Fuku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005410 abnormal fertilization "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mknk2tm1Fuku/Mknk2tm1Fuku
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr