ENSMUSG00000031553


Mus musculus

Features
Gene ID: ENSMUSG00000031553
  
Biological name :Adam3
  
Synonyms : Adam3 / A disintegrin and metallopeptidase domain 3 / F8VQ03
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 24677225
Gene end: 24725852
  
Corresponding Affymetrix probe sets: 10577685 (MoGene1.0st)   1448329_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132620
Ensembl peptide - ENSMUSP00000130818
Ensembl peptide - ENSMUSP00000132634
Ensembl peptide - ENSMUSP00000132651
Ensembl peptide - ENSMUSP00000033958
Ensembl peptide - ENSMUSP00000126617
Ensembl peptide - ENSMUSP00000127479
NCBI entrez gene - 11497     See in Manteia.
MGI - MGI:102518
RefSeq - XM_017312524
RefSeq - NM_001324489
RefSeq - NM_009619
RefSeq - XM_011242113
RefSeq - XM_011242114
RefSeq Peptide - NP_001311418
RefSeq Peptide - NP_033749
swissprot - E9QA56
swissprot - F6TMV4
swissprot - F8VQ03
swissprot - Q6P907
swissprot - E9PYS9
swissprot - E9PYS3
Ensembl - ENSMUSG00000031553
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:174164ENSDARG00000057138Danio rerio
 ENSGALG00000044168Gallus gallus
 ENSGALG00000044866Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam18 / Q9R157 / Disintegrin and metalloproteinase domain-containing protein 18 / Q9Y3Q7* / ADAM metallopeptidase domain 18*ENSMUSG0000003155234
Adam5 / Q3TTE0 / Disintegrin and metalloproteinase domain-containing protein 5 ENSMUSG0000003155432
Adam2 / Q60718 / Disintegrin and metalloproteinase domain-containing protein 2 / Q99965* / ADAM metallopeptidase domain 2*ENSMUSG0000002203932
Adam32 / Q8K410 / Disintegrin and metalloproteinase domain-containing protein 32 / Q8TC27* / ADAM metallopeptidase domain 32*ENSMUSG0000003743731
Adam9 / Q61072 / Disintegrin and metalloproteinase domain-containing protein 9 / Q13443* / ADAM metallopeptidase domain 9*ENSMUSG0000003155526
Adam1a / O54992 / Q60813 / Disintegrin and metalloproteinase domain-containing protein 1a ENSMUSG0000007264724
Adam21 / Q9JI76 / Disintegrin and metalloproteinase domain-containing protein 21 / Q9UKJ8* / ADAM metallopeptidase domain 21*ENSMUSG0000000843823
Adam1b / Q8R534 / Disintegrin and metalloproteinase domain-containing protein 1b ENSMUSG0000006243823
Adam20 / a disintegrin and metallopeptidase domain 20ENSMUSG0000004628223
Adam39 / a disintegrin and metallopeptidase domain 39ENSMUSG0000005403322
Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*ENSMUSG0000004346822
Adam24 / Q9R160 / Disintegrin and metalloproteinase domain-containing protein 24 ENSMUSG0000004672322
Adam25ENSMUSG0000007193722
Gm5346ENSMUSG0000005019022
Adam26b / a disintegrin and metallopeptidase domain 26BENSMUSG0000006390022
Q9R158 / Adam26a / Disintegrin and metalloproteinase domain-containing protein 26A ENSMUSG0000004851622
Adam34 / a disintegrin and metallopeptidase domain 34ENSMUSG0000007905822
Adam29 / ADAM metallopeptidase domain 29 / Q9UKF5*ENSMUSG0000004625821
Gm4787ENSMUSG0000007297420
Adam6a / a disintegrin and metallopeptidase domain 6AENSMUSG0000004394520


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR013111  EGF-like domain, extracellular
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007338 single fertilization IGI
 biological_processGO:0007339 binding of sperm to zona pellucida IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0050684 regulation of mRNA processing IMP
 biological_processGO:0097722 sperm motility IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0061827 sperm head IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008237 metallopeptidase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Mark2Gt(pSABetageo)38Bss/Mark2+
Genetic Background: involves: 129S2/SvPas * MF1

Allelic Composition: Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic Background: Not Specified

 MP:0004542 impaired acrosome reaction "abnormality in the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mark2Gt(pSABetageo)38Bss/Mark2+
Genetic Background: involves: 129S2/SvPas * MF1

 MP:0005410 abnormal fertilization "anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam2tm1Dgm/Adam2tm1Dgm,Adam3tm1Pmkf/Adam3tm1Pmkf
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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