ENSMUSG00000031555


Mus musculus

Features
Gene ID: ENSMUSG00000031555
  
Biological name :Adam9
  
Synonyms : Adam9 / Disintegrin and metalloproteinase domain-containing protein 9 / Q61072
  
Possible biological names infered from orthology : ADAM metallopeptidase domain 9 / Q13443
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A2
Gene start: 24949611
Gene end: 25016927
  
Corresponding Affymetrix probe sets: 10577757 (MoGene1.0st)   1416094_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081045
Ensembl peptide - ENSMUSP00000148096
Ensembl peptide - ENSMUSP00000147165
Ensembl peptide - ENSMUSP00000146545
Ensembl peptide - ENSMUSP00000081048
NCBI entrez gene - 11502     See in Manteia.
MGI - MGI:105376
RefSeq - XM_006508986
RefSeq - NM_001270996
RefSeq - NM_007404
RefSeq Peptide - NP_001257925
RefSeq Peptide - NP_031430
swissprot - E9Q638
swissprot - A0A1B0GSW1
swissprot - A0A140LHU0
swissprot - A0A140LJC9
swissprot - Q61072
Ensembl - ENSMUSG00000031555
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adam9ENSDARG00000010070Danio rerio
 ADAM9ENSGALG00000003398Gallus gallus
 ADAM9ENSG00000168615Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adam1a / O54992 / Q60813 / Disintegrin and metalloproteinase domain-containing protein 1a ENSMUSG0000007264731
Adam21 / Q9JI76 / Disintegrin and metalloproteinase domain-containing protein 21 / Q9UKJ8* / ADAM metallopeptidase domain 21*ENSMUSG0000000843830
Gm5346ENSMUSG0000005019029
Adam30 / a disintegrin and metallopeptidase domain 30 / Q9UKF2* / ADAM metallopeptidase domain 30*ENSMUSG0000004346829
Q9R158 / Adam26a / Disintegrin and metalloproteinase domain-containing protein 26A ENSMUSG0000004851629
Adam1b / Q8R534 / Disintegrin and metalloproteinase domain-containing protein 1b ENSMUSG0000006243829
Adam34 / a disintegrin and metallopeptidase domain 34ENSMUSG0000007905829
Adam29 / ADAM metallopeptidase domain 29 / Q9UKF5*ENSMUSG0000004625829
Adam32 / Q8K410 / Disintegrin and metalloproteinase domain-containing protein 32 / Q8TC27* / ADAM metallopeptidase domain 32*ENSMUSG0000003743728
Adam26b / a disintegrin and metallopeptidase domain 26BENSMUSG0000006390028
Adam20 / a disintegrin and metallopeptidase domain 20ENSMUSG0000004628228
Adam2 / Q60718 / Disintegrin and metalloproteinase domain-containing protein 2 / Q99965* / ADAM metallopeptidase domain 2*ENSMUSG0000002203927
Adam25ENSMUSG0000007193727
Adam39 / a disintegrin and metallopeptidase domain 39ENSMUSG0000005403327
Adam24 / Q9R160 / Disintegrin and metalloproteinase domain-containing protein 24 ENSMUSG0000004672326
Adam3 / F8VQ03 / A disintegrin and metallopeptidase domain 3 ENSMUSG0000003155325
Adam18 / Q9R157 / Disintegrin and metalloproteinase domain-containing protein 18 / Q9Y3Q7* / ADAM metallopeptidase domain 18*ENSMUSG0000003155225
Gm4787ENSMUSG0000007297424
Adam4 / a disintegrin and metallopeptidase domain 4ENSMUSG0000007297224
Adam6a / a disintegrin and metallopeptidase domain 6AENSMUSG0000004394524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR001590  Peptidase M12B, ADAM/reprolysin
 IPR001762  Disintegrin domain
 IPR002870  Peptidase M12B, propeptide
 IPR006586  ADAM, cysteine-rich
 IPR013032  EGF-like, conserved site
 IPR018358  Disintegrin, conserved site
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034027  Reprolysin domain, adamalysin-type
 IPR036436  Disintegrin domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006509 membrane protein ectodomain proteolysis IDA
 biological_processGO:0007155 cell adhesion ISO
 biological_processGO:0007160 cell-matrix adhesion ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0010042 response to manganese ion ISO
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0033627 cell adhesion mediated by integrin ISO
 biological_processGO:0033630 positive regulation of cell adhesion mediated by integrin ISO
 biological_processGO:0033631 cell-cell adhesion mediated by integrin IEA
 biological_processGO:0034241 positive regulation of macrophage fusion ISO
 biological_processGO:0034612 response to tumor necrosis factor ISO
 biological_processGO:0034616 response to laminar fluid shear stress IEA
 biological_processGO:0042117 monocyte activation ISO
 biological_processGO:0042542 response to hydrogen peroxide ISO
 biological_processGO:0050714 positive regulation of protein secretion ISO
 biological_processGO:0051044 positive regulation of membrane protein ectodomain proteolysis IDA
 biological_processGO:0051088 PMA-inducible membrane protein ectodomain proteolysis ISO
 biological_processGO:0051384 response to glucocorticoid IMP
 biological_processGO:0051549 positive regulation of keratinocyte migration ISO
 biological_processGO:0051592 response to calcium ion ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0031233 intrinsic component of external side of plasma membrane IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005178 integrin binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017124 SH3 domain binding IDA
 molecular_functionGO:0043236 laminin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Fgf8tm1.1Mrt/Fgf8tm1.4Mrt,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
Show

Allelic Composition: Fn1tm1Ksek/Fn1tm1Ksek,Tg(RIP1-Tag)2Dh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0002624 abnormal tricuspid valve morphology "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002724 enhanced wound healing "increased ability to self-repair and close wounds" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:42016]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0002746 abnormal semilunar valve morphology "malformation of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82728]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002748 abnormal pulmonary valve morphology "malformation of the valve between the right ventricle and the pulmonary trunk" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam17tm1Imx/Adam17tm1Imx,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010618 enlarged mitral valve "an increase in the total area occupied by the mitral valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010620 thick mitral valve 
Show

Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0010627 enlarged tricuspid valve "an increase in the total area occupied by the tricuspid valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010629 thick tricuspid valve 
Show

Allelic Composition: Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Adam12tm1Asf/Adam12tm1Asf,Adam15tm1Bbl/Adam15tm1Bbl,Adam19Gt(Betageo)1Bbl/Adam19Gt(Betageo)1Bbl,Adam9tm1Bbl/Adam9tm1Bbl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0012193 increased keratinocyte migration "increased or faster movement of keratinocyes or their precursors to the appropriate location in the body" [MGI:csmith]
Show

Allelic Composition: Scarb1Hlb398/Scarb1+
Genetic Background: C57BL/6J-Scarb1Hlb398

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr