ENSMUSG00000073725


Mus musculus

Features
Gene ID: ENSMUSG00000073725
  
Biological name :Lmbrd1
  
Synonyms : Lmbrd1 / Probable lysosomal cobalamin transporter / Q8K0B2
  
Possible biological names infered from orthology : LMBR1 domain containing 1 / Q9NUN5
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A5
Gene start: 24678630
Gene end: 24766301
  
Corresponding Affymetrix probe sets: 10345141 (MoGene1.0st)   1425186_at (Mouse Genome 430 2.0 Array)   1451622_at (Mouse Genome 430 2.0 Array)   1455617_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139893
Ensembl peptide - ENSMUSP00000140911
Ensembl peptide - ENSMUSP00000140783
Ensembl peptide - ENSMUSP00000140516
Ensembl peptide - ENSMUSP00000092672
NCBI entrez gene - 68421     See in Manteia.
MGI - MGI:1915671
RefSeq - XM_017322292
RefSeq - NM_001310483
RefSeq - NM_026719
RefSeq Peptide - NP_001297412
RefSeq Peptide - NP_080995
swissprot - Q8K0B2
swissprot - A0A087WS60
swissprot - A0A087WPS2
swissprot - A0A087WR85
Ensembl - ENSMUSG00000073725
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lmbrd1ENSDARG00000104223Danio rerio
 LMBRD1ENSGALG00000016174Gallus gallus
 LMBRD1ENSG00000168216Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006876  LMBR1-like membrane protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0038016 insulin receptor internalization IMP
 biological_processGO:0046325 negative regulation of glucose import IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IMP
 biological_processGO:0051898 negative regulation of protein kinase B signaling IMP
 cellular_componentGO:0005764 lysosome IDA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle IDA
 molecular_functionGO:0005158 insulin receptor binding IDA
 molecular_functionGO:0031419 cobalamin binding IEA


Pathways (from Reactome)
Pathway description
Cobalamin (Cbl, vitamin B12) transport and metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004039 abnormal cardiac cell glucose uptake "anomalous ability of the cells of the heart to take in glucose" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Lamb3tm1b(KOMP)Wtsi/Lamb3tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lamb3tm1b(KOMP)Wtsi/H

 MP:0030018 increased cardiac cell glucose uptake "increased ability of the cells of the heart to take in glucose" [MGI:anna]
Show

Allelic Composition: Mus81tm1Chmg/Mus81tm1Chmg,Slx1btm1.1Jrou/Slx1btm1.1Jrou
Genetic Background: involves: 129P2/OlaHsd * 129S5/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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