ENSMUSG00000076441


Mus musculus

Features
Gene ID: ENSMUSG00000076441
  
Biological name :Ass1
  
Synonyms : Argininosuccinate synthase / Ass1 / P16460
  
Possible biological names infered from orthology : argininosuccinate synthase 1 / P00966
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: B
Gene start: 31470207
Gene end: 31520672
  
Corresponding Affymetrix probe sets: 10363541 (MoGene1.0st)   10471154 (MoGene1.0st)   1416239_at (Mouse Genome 430 2.0 Array)   1459937_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099904
NCBI entrez gene - 11898     See in Manteia.
MGI - MGI:88090
RefSeq - NM_007494
RefSeq Peptide - NP_031520
swissprot - P16460
swissprot - Q3UJ34
Ensembl - ENSMUSG00000076441
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ASS1ENSGALG00000023689Gallus gallus
 ASS1ENSG00000130707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001518  Argininosuccinate synthase
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR018223  Argininosuccinate synthase, conserved site
 IPR023434  Argininosuccinate synthase, type 1 subfamily
 IPR024074  Argininosuccinate synthetase, catalytic/multimerisation domain body


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000050 urea cycle ISO
 biological_processGO:0000052 citrulline metabolic process IEA
 biological_processGO:0000053 argininosuccinate metabolic process IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0006526 arginine biosynthetic process ISO
 biological_processGO:0006531 aspartate metabolic process IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0007494 midgut development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0010046 response to mycotoxin IEA
 biological_processGO:0014075 response to amine IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0060416 response to growth hormone IEA
 biological_processGO:0060539 diaphragm development IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071242 cellular response to ammonium ion IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071377 cellular response to glucagon stimulus IEA
 biological_processGO:0071400 cellular response to oleic acid IEA
 biological_processGO:0071418 cellular response to amine stimulus IEA
 biological_processGO:0071499 cellular response to laminar fluid shear stress IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:1903038 negative regulation of leukocyte cell-cell adhesion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0070852 cell body fiber IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004055 argininosuccinate synthase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015643 toxic substance binding IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Urea cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000377 abnormal hair follicle "malformed invagination of the epidermis from which the hair shaft develops" [J:65031]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0000422 delayed hair appearance "late onset of the first appearance of the fur" [J:17792]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ass1tm1.1Ekoe/Ass1tm1.2Ekoe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
Show

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(CAG-EGFP/Map1lc3b)53Nmz/0,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Ass1tm1.1Ekoe/Ass1tm1.2Ekoe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

 MP:0003704 abnormal hair follicle development "anomalous development of the epidermis from which the hair shaft develops " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-J/Mbpshi-J
Genetic Background: BALB/cJ-Mbpshi-J/GrsrJ

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

Allelic Composition: Ass1tm1Bay/Ass1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

Allelic Composition: Ass1tm1.1Ekoe/Ass1tm1.1Ekoe,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ass1tm1.1Ekoe/Ass1tm1.1Ekoe,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ass1fold/Ass1fold
Genetic Background: B6Ei.P-Ass1fold/GrsrJ

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1fold
Genetic Background: involves: C57BL/6Ei * C57BL/6J * OF1 * P/J

 MP:0010387 abnormal Bergmann glial cell morphology "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: FVB.BAR-Ass1bar

Allelic Composition: Ass1bar/Ass1bar
Genetic Background: B6.BAR-Ass1bar

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: ApcMin/ApcMin,Asphtm1Jed/Asphtm1Jed
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * C57BL/6NTac

Allelic Composition: Ass1tm1.2Ekoe/Ass1tm1.2Ekoe
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063445 Nmral1 / Q8K2T1 / NmrA-like family domain-containing protein 1 / Q9HBL8* / NmrA like redox sensor 1*  / complex
 ENSMUSG00000076441 Ass1 / P16460 / Argininosuccinate synthase / P00966* / argininosuccinate synthase 1*  / complex






 

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