ENSMUSG00000078789


Mus musculus

Features
Gene ID: ENSMUSG00000078789
  
Biological name :Dph1
  
Synonyms : 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 / Dph1 / Q5NCQ5
  
Possible biological names infered from orthology : diphthamide biosynthesis 1 / Q9BZG8
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 75177643
Gene end: 75191241
  
Corresponding Affymetrix probe sets: 10388392 (MoGene1.0st)   1418335_a_at (Mouse Genome 430 2.0 Array)   1432149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116537
Ensembl peptide - ENSMUSP00000042162
NCBI entrez gene - 116905     See in Manteia.
MGI - MGI:2151233
RefSeq - NM_144491
RefSeq Peptide - NP_652762
swissprot - B1ARH1
swissprot - Q5NCQ5
Ensembl - ENSMUSG00000078789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dph1ENSDARG00000057973Danio rerio
 DPH1ENSGALG00000003082Gallus gallus
 DPH1ENSG00000108963Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016435  Diphthamide synthesis DPH1/DPH2
 IPR035435  Diphthamide synthesis DHP1/DPH2, eukaryotes and archaea


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of diphthamide-EEF2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002116 abnormal craniofacial bone morphology "abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm1Bhr/Dph1tm2Bhr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm1Bhr/Dph1tm2Bhr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0004470 small nasal bone "reduced size of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0004471 short nasal bone "reduced length of either of two rectangular bone plates forming the bridge of the nose" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0004476 absent palatine bone "absence of either of two irregularly shaped bones that form the back of the hard palate and helps to form the nasal cavity and the floor of the orbits" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Eef2tm1.1Lepp/Eef2+
Genetic Background: involves: C57BL/6

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eef2tm1.1Lepp/Eef2+
Genetic Background: involves: C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm1Bhr/Dph1tm2Bhr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0009579 acephaly "congenital absence of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0009655 abnormal secondary palate development "any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:16942766]
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Allelic Composition: Srftm1Rmn/Srftm1Rmn,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010308 decreased tumor latency "earlier onset of tumor occurrence than expected" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm1Bhr/Dph1tm2Bhr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Dph1tm2Bhr/Dph1+,Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Mesp1tm2(cre)Ysa/Mesp1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm1Bhr/Dph1tm2Bhr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: KitW-1Bao/Kit+
Genetic Background: C57BL/6J-KitW-1Bao

Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Eef2tm1.1Lepp/Eef2+
Genetic Background: involves: C57BL/6

 MP:0011862 decreased cranium length "having an decreased dorsal-to-ventral distance of the cranium" [MGI:mnk]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0012240 abnormal hepatoblast morphology "any structural anomaly of the bi-potent cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes" [MGI:anna]
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0013933 short Meckel s cartilage 
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Allelic Composition: Dph1tm2Bhr/Dph1tm2Bhr
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0030072 round face "facial appearance is more circular than usual as viewed from the front" [HP:0000311]
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Allelic Composition: Dph1tm1.1Cmch/Dph1tm1.1Cmch,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021905 Dph3 / Q8K0W9 / DPH3 homolog / Q96FX2* / diphthamide biosynthesis 3*  / complex
 ENSMUSG00000028540 Dph2 / Q9CR25 / 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 / Q9BQC3* / DPH2 homolog*  / complex






 

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