ENSMUSG00000021905


Mus musculus

Features
Gene ID: ENSMUSG00000021905
  
Biological name :Dph3
  
Synonyms : Dph3 / DPH3 homolog / Q8K0W9
  
Possible biological names infered from orthology : diphthamide biosynthesis 3 / Q96FX2
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 32080566
Gene end: 32085729
  
Corresponding Affymetrix probe sets: 10418796 (MoGene1.0st)   1431200_a_at (Mouse Genome 430 2.0 Array)   1433921_s_at (Mouse Genome 430 2.0 Array)   1455268_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120583
Ensembl peptide - ENSMUSP00000127944
Ensembl peptide - ENSMUSP00000022461
Ensembl peptide - ENSMUSP00000068491
NCBI entrez gene - 105638     See in Manteia.
MGI - MGI:1922658
RefSeq - NM_001047433
RefSeq - NM_001284346
RefSeq - NM_172254
RefSeq Peptide - NP_001271275
RefSeq Peptide - NP_758458
RefSeq Peptide - NP_001040898
swissprot - Q8K0W9
swissprot - D3YXV3
swissprot - E9PZC5
Ensembl - ENSMUSG00000021905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dph3ENSDARG00000043360Danio rerio
 DPH3ENSGALG00000011237Gallus gallus
 DPH3ENSG00000154813Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007872  Zinc finger, DPH-type
 IPR036671  DPH Zinc finger superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine ISS
 biological_processGO:0050709 negative regulation of protein secretion IEA
 biological_processGO:0051099 positive regulation of binding IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of diphthamide-EEF2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0004188 delayed embryo turning "completion of axial rotation occurs later than in controls but is eventually completed" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

 MP:0012509 neural tube degeneration "a retrogressive impairment of function or destruction of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)" [MGI:anna]
Show

Allelic Composition: Kat6atm1Avo/Kat6a+
Genetic Background: involves: 129 * BALB/c * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078789 Dph1 / Q5NCQ5 / 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 / Q9BZG8* / diphthamide biosynthesis 1*  / complex
 ENSMUSG00000028540 Dph2 / Q9CR25 / 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 / Q9BQC3* / DPH2 homolog*  / complex






 

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