ENSMUSG00000028540


Mus musculus

Features
Gene ID: ENSMUSG00000028540
  
Biological name :Dph2
  
Synonyms : 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 / Dph2 / Q9CR25
  
Possible biological names infered from orthology : DPH2 homolog / Q9BQC3
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.1
Gene start: 117888643
Gene end: 117892032
  
Corresponding Affymetrix probe sets: 10515528 (MoGene1.0st)   1452647_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030265
Ensembl peptide - ENSMUSP00000138948
NCBI entrez gene - 67728     See in Manteia.
MGI - MGI:1914978
RefSeq - NM_026344
RefSeq Peptide - NP_080620
swissprot - Q9CR25
swissprot - V9GX25
Ensembl - ENSMUSG00000028540
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dph2ENSDARG00000078077Danio rerio
 DPH2ENSGALG00000010089Gallus gallus
 DPH2ENSG00000132768Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010014  Diphthamide synthesis DHP2, eukaryotes
 IPR016435  Diphthamide synthesis DPH1/DPH2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine IBA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0090560 2-(3-amino-3-carboxypropyl)histidine synthase activity ISO


Pathways (from Reactome)
Pathway description
Synthesis of diphthamide-EEF2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021905 Dph3 / Q8K0W9 / DPH3 homolog / Q96FX2* / diphthamide biosynthesis 3*  / complex
 ENSMUSG00000034994 Eef2 / P58252 / Elongation factor 2 / P13639* / eukaryotic translation elongation factor 2*  / reaction
 ENSMUSG00000078789 Dph1 / Q5NCQ5 / 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 / Q9BZG8* / diphthamide biosynthesis 1*  / complex






 

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