ENSMUSG00000034994


Mus musculus

Features
Gene ID: ENSMUSG00000034994
  
Biological name :Eef2
  
Synonyms : Eef2 / Elongation factor 2 / P58252
  
Possible biological names infered from orthology : eukaryotic translation elongation factor 2 / P13639
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81176631
Gene end: 81182498
  
Corresponding Affymetrix probe sets: 10364990 (MoGene1.0st)   1424736_at (Mouse Genome 430 2.0 Array)   1440784_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046101
NCBI entrez gene - 13629     See in Manteia.
MGI - MGI:95288
RefSeq - NM_007907
RefSeq Peptide - NP_031933
swissprot - P58252
Ensembl - ENSMUSG00000034994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eef2l2ENSDARG00000035256Danio rerio
 EEF2ENSGALG00000033884Gallus gallus
 EEF2ENSG00000167658Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000640  Elongation factor EFG, domain V-like
 IPR000795  Transcription factor, GTP-binding domain
 IPR004161  Translation elongation factor EFTu-like, domain 2
 IPR005225  Small GTP-binding protein domain
 IPR005517  Translation elongation factor EFG/EF2, domain IV
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031157  Tr-type G domain, conserved site
 IPR035647  EF-G domain III/V-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0003009 skeletal muscle contraction IEA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0014009 glial cell proliferation IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0051593 response to folic acid IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 biological_processGO:2000767 positive regulation of cytoplasmic translation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016235 aggresome IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0042788 polysomal ribosome IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003746 translation elongation factor activity IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008097 5S rRNA binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Peptide chain elongation
Synthesis of diphthamide-EEF2
Neutrophil degranulation
Protein methylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

Allelic Composition: Eef2tm1.1Lepp/Eef2+
Genetic Background: involves: C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

Allelic Composition: Eef2tm1.1Lepp/Eef2+
Genetic Background: involves: C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Zfp36tm1.2Xen/Zfp36tm1.2Xen
Genetic Background: C57BL/6-Zfp36tm1.2Xen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033554 Dph5 / Q9CWQ0 / Diphthine methyl ester synthase / Q9H2P9* / diphthamide biosynthesis 5*  / reaction
 ENSMUSG00000057147 Dph6 / Q9CQ28 / Mus musculus diphthamine biosynthesis 6 (Dph6), transcript variant 3, mRNA. / Q7L8W6* / diphthamine biosynthesis 6*  / reaction
 ENSMUSG00000028540 Dph2 / Q9CR25 / 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 / Q9BQC3* / DPH2 homolog*  / reaction
 ENSMUSG00000022544 Q3UZW7 / Eef2kmt / Protein-lysine N-methyltransferase EEF2KMT / Q9NVL1* / P0C5J1* / Q8N7N1* / Q96G04* / FAM86B1* / FAM86B2* / FAM86C1* / family with sequence similarity 86 member C1* / fam...  / reaction






 

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