Manteia

ENSMUSG00000057147

Mus musculus

Features

Gene ID:	ENSMUSG00000057147

Biological name :	Dph6

Synonyms :	Dph6 / Mus musculus diphthamine biosynthesis 6 (Dph6), transcript variant 3, mRNA. / Q9CQ28

Possible biological names infered from orthology :	diphthamine biosynthesis 6 / Q7L8W6

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	E4
Gene start:	114516416
Gene end:	114654964

Corresponding Affymetrix probe sets:	10486029 (MoGene1.0st) 1426548_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000028640 Ensembl peptide - ENSMUSP00000060730 Ensembl peptide - ENSMUSP00000099601 NCBI entrez gene - 66632 See in Manteia. MGI - MGI:1913882 RefSeq - XM_006500018 RefSeq - NM_001356439 RefSeq - NM_025675 RefSeq Peptide - NP_079951 RefSeq Peptide - NP_001343368 swissprot - Q9CQ28 Ensembl - ENSMUSG00000057147

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dph6	ENSDARG00000042839	Danio rerio
DPH6	ENSGALG00000020438	Gallus gallus
DPH6	ENSG00000134146	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR002761	Diphthamide synthase domain
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
IPR030662	Diphthine--ammonia ligase/Uncharacterised protein MJ0570

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0017183	peptidyl-diphthamide biosynthetic process from peptidyl-histidine	IEA
biological_process	GO:0031647	regulation of protein stability	ISO
biological_process	GO:1903955	positive regulation of protein targeting to mitochondrion	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005730	nucleolus	ISO
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016874	ligase activity	IEA
molecular_function	GO:0017178	diphthine-ammonia ligase activity	ISO

Pathways (from Reactome)

Pathway description

Synthesis of diphthamide-EEF2

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002075	abnormal coat color	"irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003036	vertebral transformation	"homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008040	decreased NK T cell number	"reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010102	increased caudal vertebrae number	"increased number of the bony segments of the coccyx or tail" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010168	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010844	increased effector memory CD4-positive, alpha-beta T cell number	"increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000905, GO_REF:0000031, GOC:add, GOC:pam, GOC:tfm]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010850	increased effector memory CD8-positive, alpha-beta T cell number	"increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0012765	decreased alpha-beta T cell number	"reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013023	decreased Ly6C high monocyte number	"decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013025	increased Ly6C low monocyte number	"increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013157	increased KLRG1+ CD4 alpha beta T cell number	"increase in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells" [MGI:csmith]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013433	increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"increase in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation" [IMPC:Saran, PMID:19479342]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013764	decreased T-helper cell number	"reduction in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]	Show Allelic Composition: Clrn1^{tm1.1(KOMP)Vlcg}/Clrn1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Clrn1^{tm1.1(KOMP)Vlcg}/Ucd

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000034994	Eef2 / P58252 / Elongation factor 2 / P13639* / eukaryotic translation elongation factor 2*	/ reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr