ENSG00000134146


Homo sapiens

Features
Gene ID: ENSG00000134146
  
Biological name :DPH6
  
Synonyms : diphthamine biosynthesis 6 / DPH6 / Q7L8W6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q14
Gene start: 35217345
Gene end: 35546193
  
Corresponding Affymetrix probe sets: 1560404_a_at (Human Genome U133 Plus 2.0 Array)   238662_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000256538
Ensembl peptide - ENSP00000406976
Ensembl peptide - ENSP00000453967
Ensembl peptide - ENSP00000454015
NCBI entrez gene - 89978     See in Manteia.
RefSeq - XM_017022709
RefSeq - NM_001141972
RefSeq - NM_080650
RefSeq - XM_011522160
RefSeq - XM_017022707
RefSeq - XM_017022708
RefSeq Peptide - NP_001135444
RefSeq Peptide - NP_542381
swissprot - H0YNH5
swissprot - Q7L8W6
swissprot - H0YND7
Ensembl - ENSG00000134146
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dph6ENSDARG00000042839Danio rerio
 DPH6ENSGALG00000020438Gallus gallus
 Dph6ENSMUSG00000057147Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002761  Diphthamide synthase domain
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR030662  Diphthine--ammonia ligase/Uncharacterised protein MJ0570


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine TAS
 biological_processGO:0031647 regulation of protein stability IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0017178 diphthine-ammonia ligase activity EXP


Pathways (from Reactome)
Pathway description
Synthesis of diphthamide-EEF2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000167658 EEF2 / P13639 / eukaryotic translation elongation factor 2  / reaction






 

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