Manteia

ID

Phenotype

Definition

Genetic BG

increased WBC count

"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]

Show

Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi}
Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi

MP:0000379

reduced hair follicle number

"fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]

Show

Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/?,Tnni3k^tm1Tfo/Tnni3k^tm1Tfo
Genetic Background: involves: C57BL/6 * FVB/N

MP:0000414

alopecia

"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0000416

sparse fur

"fur that is significantly less dense" [J:46854]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0000648

absent sebaceous gland

"missing the holocrine glands of the dermis that secrete sebum into the hair follicles" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]

Show

Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/?,Tnni3k^tm1Tfo/Tnni3k^tm1Tfo
Genetic Background: involves: C57BL/6 * FVB/N

MP:0001192

scaly skin

"skin covered with shedding scales or flakes" [J:65146]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0001193

psoriasis

"chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0001194

dermatitis

"inflammation of the skin" [J:65146]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0001212

skin lesions

"focal patches of inflammation on the skin" [J:30162]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0001219

thickened epidermis

"increase in the width of the epidermal cell layer in the skin" [J:65146]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0001242

hyperkeratosis

"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0001874

acanthosis

"diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0002074

abnormal hair texture

"irregular or unusual appearance of the structure of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]

Show

Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi}
Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi

MP:0002590

increased mean corpuscular volume

"greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]

Show

Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi}
Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi

MP:0002656

abnormal keratinocyte differentiation

"developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0003427

parakeratosis

"abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0003853

dry skin

"skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0005501

abnormal skin physiology

"atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0005567

decreased circulating total protein level

"less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]

Show

Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi}
Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi

MP:0009931

abnormal skin appearance

"skin that looks different from the usual state" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

MP:0010088

decreased circulating fructosamine level

"decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]

Show

Allelic Composition: Ap4e1^{tm1a(KOMP)Wtsi}/Ap4e1^{tm1a(KOMP)Wtsi}
Genetic Background: C57BL/6N-Ap4e1^{tm1a(KOMP)Wtsi}/Wtsi

MP:0030529

abnormal head skin morphology

"any anomaly in a zone of skin that is part of the head" [UBERON:0001084]

Show

Allelic Composition: Arpc4^{tm1c(EUCOMM)Wtsi}/Arpc4^{tm1c(EUCOMM)Wtsi},Krt14^tm1(cre)Wbm/Krt14⁺
Genetic Background: B6.Cg-Arpc4^{tm1c(EUCOMM)Wtsi} Krt14^tm1(cre)Wbm

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

ENSMUSG00000079426